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首页> 外文期刊>American journal of primatology >Destabilization of the gut microbiome marks the end‐stage of simian immunodeficiency virus infection in wild chimpanzees
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Destabilization of the gut microbiome marks the end‐stage of simian immunodeficiency virus infection in wild chimpanzees

机译：肠道微生物组的稳定化标志着野生黑猩猩猿猴免疫缺陷病毒感染的最终阶段

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> Enteric dysbiosis is a characteristic feature of progressive human immunodeficiency virus type 1 (HIV‐1) infection but has not been observed in simian immunodeficiency virus (SIVmac)‐infected macaques, including in animals with end‐stage disease. This has raised questions concerning the mechanisms underlying the HIV‐1 associated enteropathy, with factors other than virus infection, such as lifestyle and antibiotic use, implicated as playing possible causal roles. Simian immunodeficiency virus of chimpanzees (SIVcpz) is also associated with increased mortality in wild‐living communities, and like HIV‐1 and SIVmac, can cause CD4 + T cell depletion and immunodeficiency in infected individuals. Given the central role of the intestinal microbiome in mammalian health, we asked whether gut microbial constituents could be identified that are indicative of SIVcpz status and/or disease progression. Here, we characterized the gut microbiome of SIVcpz‐infected and ‐uninfected chimpanzees in Gombe National Park, Tanzania. Subjecting a small number of fecal samples ( N? =?9) to metagenomic (shotgun) sequencing, we found bacteria of the family Prevotellaceae to be enriched in SIVcpz‐infected chimpanzees. However, 16S rRNA gene sequencing of a larger number of samples ( N? =?123) failed to show significant differences in both the composition and diversity (alpha and beta) of gut bacterial communities between infected ( N? =?24) and uninfected ( N? =?26) chimpanzees. Similarly, chimpanzee stool‐associated circular virus (Chi‐SCV) and chimpanzee adenovirus (ChAdV) identified by metagenomic sequencing were neither more prevalent nor more abundant in SIVcpz‐infected individuals. However, fecal s
机译： <部分XML：ID =“AJP22515-SEC-0001”>

肠道困难是进步人体免疫缺陷病毒类型1（HIV-1）的特征感染但尚未观察到Simian免疫缺陷病毒（Sivmac） - 摄入的猕猴，包括患有终级疾病的动物。这提出了有关HIV-1相关肠病的机制的问题，这些机制具有除病毒感染之外的因素，例如生活方式和抗生素使用，涉及扮演可能的因果角色。黑猩猩（SiVCPZ）的Simian免疫缺陷病毒也与野生生活社区的死亡率增加，如HIV-1和SiVMAC，可导致CD4 + T细胞耗尽和受感染的个体的免疫缺陷。鉴于肠道微生物组在哺乳动物健康中的核心作用，我们询问肠道微生物成分是否可以识别，这表明SIVCPZ状态和/或疾病进展。在这里，我们在坦桑尼亚甘姆国家公园的肠道肠道感染和丛中的黑猩猩的肠道微生物组。使少量粪便样品（ N = =Δ9）进行缩放（霰弹枪）测序，我们发现家庭的细菌 PREVOTELLACEAE 在Sivcpz感染的黑猩猩中富集。然而，16S rRNA基因测序较大数量的样品（ N = = =β123）未能显示出在感染之间的细菌社区的组成和多样性（α和β）的显着差异（< i> n？ =？24），未染成（ n？ =？26）黑猩猩。同样地，通过偏心组测序鉴定的黑猩猩粪便相关的圆形病毒（Chimpanzee腺病毒（Chaff）既不普遍存在，在Sivpz感染的个体中也不富裕。但是，粪便

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