...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Allergy >Antenatal vitamin D exposure and childhood eczema, food allergy, asthma and allergic rhinitis at 2 and 5 years of age in the atopic disease‐specific Cork BASELINE BASELINE Birth Cohort Study
【24h】

Antenatal vitamin D exposure and childhood eczema, food allergy, asthma and allergic rhinitis at 2 and 5 years of age in the atopic disease‐specific Cork BASELINE BASELINE Birth Cohort Study

机译：患有特定疾病特异性软木塞基线基线基线基线诞生队列基线分娩队列群体队列群体队列队列群体队列队列群体队列群体队列队列群体队列群体队列群体队列群体队列群体队列群体队列队列群体队列群体研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Background Prospective studies of antenatal and infant vitamin D exposure and atopic disease from extensively characterised, disease‐specific, maternal‐infant cohorts with gold standard analysis of vitamin D status and clinically validated atopic outcomes are lacking. This study aimed to investigate associations between intrauterine vitamin D status and atopic outcomes in an extensively characterised, disease‐specific, maternal‐infant cohort. Methods Circulating 25‐hydroxyvitamin D (25( OH )D) was measured in maternal sera at 15 weeks of gestation (n = 1537) and umbilical cord blood ( n = 1050) using a CDC ‐accredited LC ‐ MS / MS platform, and the association with clinically validated atopic disease outcomes (eczema, food allergy, asthma, allergic rhinitis) at 2 and 5 years was explored using multivariable logistic regression. Results Persistent eczema in the first 2 years of life was present in 5% of infants. Food allergy at 2 years was confirmed in 4%. The prevalence of aeroallergen sensitisation at 2 years was 8%. Asthma at 5 years was reported in 15% and allergic rhinitis in 5% of 5‐year‐olds. There were no significant differences in the distributions of maternal 25( OH )D at 15 weeks of gestation (mean [ SD ] 58.4 [26.2] and 58.5 [26.1] nmol/L) and cord 25( OH )D concentrations (mean [ SD ] 35.2 [17.8] and 35.4 [18.3] nmol/L) between children with and without atopic disease. Neither maternal ( aOR [95% CI ]: 1.02 [0.97, 1.08], P = 0.450) nor cord 25( OH )D ( aOR [95% CI ]: 1.00 [0.91, 1.09], P = 0.991) were significant predictors of atopic disease outcomes in fully adjusted models. Conclusion These data in a disease‐specific cohort with prospectively collected, validated atopic outcomes do not support an association between antenatal exposure to vitamin D and atopic disease outcomes in childhood.
机译：摘要产前表现出产水和婴儿维生素D暴露的前瞻性研究，缺乏疾病特异性，疾病特异性，母婴群，缺乏金属素D状态和临床验证的特应结果的疾病特异性母婴群。本研究旨在调查宫内生杂蛋白D状态和特征成果之间的关联，在广泛的特征，疾病特异性的母婴队列中。方法在妊娠（n = 1537）和脐带血（n = 1050）的母体血清中测量循环25-羟基vitamind（25（OH）d），使用CDC-accredited的LC - MS / MS平台，利用多变量的逻辑回归探讨了与临床验证的特应性疾病结果（湿疹，食物过敏，哮喘，过敏性鼻炎）的关联。结果在5％的婴儿的生命中存在持续的湿疹。 2年的食物过敏确认为4％。 2岁时气泡剂致敏的患病率为8％。 5年来哮喘患有15％，5％的5％的过敏性鼻炎。在妊娠15周（平均值58.4 [26.2]和58.5 [26.1] Nmol / L）和绳索25（OH）D浓度（平均值[SD] 58.4和58.5] D浓度（平均值[SD ] 35.2 [17.8]和35.4 [18.3] Nmol / L）有和没有应具体疾病的儿童。母亲（AOR [95％ci]：1.02 [0.97,1.08]，p = 0.450），p = 0.450）和绳索25（OH）D（aor [95％ci]：1.00 [0.91,1.09]，p = 0.991）是显着的预测因子完全调整模型的特应疾病结果。结论这些数据在疾病特异性群组中，验证了验证的特应结果不支持产前暴露于儿童的维生素D和特应性疾病结果之间的关联。

著录项

  • 来源
    《Allergy》 |2018年第11期|共10页
  • 作者

    Hennessy áine; Hourihane Jonathan OB; Malvisi Lucio; Irvine Alan D.; Kenny Louise C.; Murray Deirdre M.; Kiely Mairead E.;

  • 作者单位

    Cork Centre for Vitamin D and Nutrition ResearchUniversity College CorkCork Ireland;

    The Irish Centre for Fetal and Neonatal Translational Research (INFANT)University College CorkCork;

    Cork Centre for Vitamin D and Nutrition ResearchUniversity College CorkCork Ireland;

    The Irish Centre for Fetal and Neonatal Translational Research (INFANT)University College CorkCork;

    Department of Women's and Children's HealthUniversity of LiverpoolLiverpool UK;

    The Irish Centre for Fetal and Neonatal Translational Research (INFANT)University College CorkCork;

    Cork Centre for Vitamin D and Nutrition ResearchUniversity College CorkCork Ireland;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    allergy; asthma; atopic disease; pregnancy; vitamin D;

    机译：过敏;哮喘;特应疾病;怀孕;维生素D;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号