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首页> 外文期刊>Allergy >Artemisia pollen allergy in China: Component-resolved diagnosis reveals allergic asthma patients have significant multiple allergen sensitization
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Artemisia pollen allergy in China: Component-resolved diagnosis reveals allergic asthma patients have significant multiple allergen sensitization

机译：艾蒿的花粉过敏在中国：组件解决诊断显示过敏性哮喘患者具有显着的多重过敏原致敏性

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摘要

Background Artemisia pollen allergy is a major cause of asthma in Northern China. Possible associations between IgE responses to Artemisia allergen components and clinical phenotypes have not yet been evaluated. This study was to establish sensitization patterns of four Artemisia allergens and possible associations with demographic characteristics and clinical phenotypes in three areas of China. Methods Two hundred and forty patients allergic to Artemisia pollen were examined, 178 from Shanxi and 30 from Shandong Provinces in Northern China, and 32 from Yunnan Province in Southwestern China. Allergic asthma, rhinitis, conjunctivitis, and eczema symptoms were diagnosed. All patients' sera were tested by ImmunoCAP with mugwort pollen extract and the natural components nArt v 1, nArt ar 2, nArt v 3, and nArt an 7. Results The frequency of sensitization and the IgE levels of the four components in Artemisia allergic patients from Southwestern China were significantly lower than in those from the North. Art v 1 and Art an 7 were the most frequently recognized allergens (84% and 87%, respectively), followed by Art v 3 (66%) and Art ar 2 (48%). Patients from Northern China were more likely to have allergic asthma (50%) than patients from Southwestern China (3%), and being sensitized to more than two allergens increased the risk of allergic asthma, in which co-sensitization to three major allergens Art v 1, Art v 3, and Art an 7 is prominent. Conclusions Component-resolved diagnosis of Chinese Artemisia pollen-allergic patients helps assess the potential risk of mugwort-associated allergic asthma.
机译：背景蒿属植物花粉过敏是中国北方哮喘的主要原因。尚未评估对蒿属植物过敏原组分和临床表型的IgE反应之间的可能组合。本研究是建立四个蒿属植物过敏原的致敏模式，以及中国三个地区的人口统计特征和临床表型可能的关联。方法检查二百款对蒿属花粉过敏的患者，从山西178名和中国北部山东省30分，32岁于中国西南部。诊断出过敏性哮喘，鼻炎，结膜炎和湿疹症状。所有患者的血清都是用Mugwort Pollen提取物和NART V 1，NART AR 2，NART V 3和NART测试的所有患者的血清。结果令人敏感患者的致敏频率和四种组分的敏感性和IGE水平从中国西南部显着低于北方的人。 ART V 1和ART 7是最常见的过敏原（分别为84％和87％），其次是ART V 3（66％）和ART 2（48％）。来自中国北方的患者比来自中国西南部（3％）的患者更容易出现过敏性哮喘（50％），并且敏感到两种以上的过敏原增加过敏性哮喘的风险，其中对三个主要过敏原艺术的共同敏化V 1，艺术V 3和艺术A 7是突出的。结论组分分辨诊断中国蒿属植物花粉过敏患者有助于评估Mugwort相关过敏性哮喘的潜在风险。

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  • 来源
    《Allergy》 |2019年第2期|共10页
  • 作者

    Gao Zhongshan; Fu Wan-Yi; Sun Yuemei; Gao Biyuan; Wang Hui-Ying; Liu Meiling; Luo Fang-Mei; Zhou Xiang; Jin Jing; Zhao Lan; Wu Shandong; Liu Yi; Wu Lingying; Wang Xuefeng; Tang Ning-Bo; Guo Bao-Hua; Feng Yan; Zhou Jian Ying; Gadermaier Gabriele; Ferreira Fatima; Versteeg Serge A.; van Ree Ronald;

  • 作者单位

    Zhejiang Univ Allergy Res Ctr Hangzhou Zhejiang Peoples R China;

    Zhejiang Univ Coll Agr &

    Biotechnol Hangzhou Zhejiang Peoples R China;

    Yu Huang Ding Hosp Dept Allergy Yantai Peoples R China;

    Hangzhou Aileji Biotech Ltd Hangzhou Zhejiang Peoples R China;

    Zhejiang Univ Affiliated Hosp 2 Dept Allergy Coll Med Hangzhou Zhejiang Peoples R China;

    Third Peoples Hosp Datong Dept Allergy Datong Shanxi Peoples R China;

    Qujing Chinese Tradit Med Hosp Dept Otorhinolaryngol Qujing Yunnan Peoples R China;

    Zhejiang Univ Coll Agr &

    Biotechnol Hangzhou Zhejiang Peoples R China;

    Zhejiang Univ Coll Agr &

    Biotechnol Hangzhou Zhejiang Peoples R China;

    Zhejiang Univ Coll Agr &

    Biotechnol Hangzhou Zhejiang Peoples R China;

    Zhejiang Univ Allergy Res Ctr Hangzhou Zhejiang Peoples R China;

    Zhejiang Univ Allergy Res Ctr Hangzhou Zhejiang Peoples R China;

    Third Peoples Hosp Datong Dept Allergy Datong Shanxi Peoples R China;

    Third Peoples Hosp Datong Dept Allergy Datong Shanxi Peoples R China;

    Yu Huang Ding Hosp Dept Allergy Yantai Peoples R China;

    Qujing Chinese Tradit Med Hosp Dept Otorhinolaryngol Qujing Yunnan Peoples R China;

    Shanxi Med Univ Affiliated Hosp 1 Dept Otorhinolaryngol Taiyuan Shanxi Peoples R China;

    Zhejiang Univ Affiliated Hosp 1 Coll Med Dept Resp Dis Hangzhou Zhejiang Peoples R China;

    Univ Salzburg Dept Biosci Salzburg Austria;

    Univ Salzburg Dept Biosci Salzburg Austria;

    Univ Amsterdam Amsterdam UMC Dept Expt Immunol Amsterdam Netherlands;

    Univ Amsterdam Amsterdam UMC Dept Expt Immunol Amsterdam Netherlands;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    Artemisia pollen allergy; asthma; component-resolved diagnosis;

    机译：艾蒿花粉过敏;哮喘;组分解决诊断;

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