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首页> 外文期刊>Allergy >Proteolytic, lipidergic and polysaccharide molecular recognition shape innate responses to house dust mite allergens
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Proteolytic, lipidergic and polysaccharide molecular recognition shape innate responses to house dust mite allergens

机译：蛋白水解，脂肪酸和多糖的分子识别形状的原始反应对房屋粉尘螨虫过敏原

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Abstract House dust mites (HDMs) are sources of an extensive repertoire of allergens responsible for a range of allergic conditions. Technological advances have accelerated the identification of these allergens and characterized their putative roles within HDMs. Understanding their functional bioactivities is illuminating how they interact with the immune system to cause disease and how interrelations between them are essential to maximize allergic responses. Two types of allergen bioactivity, namely proteolysis and peptidolipid/lipid binding, elicit IgE and stimulate bystander responses to unrelated allergens. Much of this influence arises from Toll‐like receptor (TLR) 4 or TLR2 signalling and, in the case of protease allergens, the activation of additional pleiotropic effectors with strong disease linkage. Of related interest is the interaction of HDM allergens with common components of the house dust matrix, through either their binding to allergens or their autonomous modulation of immune receptors. Herein, we provide a contemporary view of how proteolysis, lipid‐binding activity and interactions with polysaccharides and polysaccharide molecular recognition systems coordinate the principal responses which underlie allergy. The power of the catalytically competent group 1 HDM protease allergen component is demonstrated by a review of disclosures surrounding the efficacy of novel inhibitors produced by structure‐based design.
机译：摘要房屋尘螨（HDMS）是一个广泛的过敏原的遗传来源，负责一系列过敏条件。技术进步加速了这些过敏原的鉴定，并表征了HDMS的推定作用。了解其功能性生物活跃性是照亮它们如何与免疫系统相互作用，导致疾病以及它们之间的相互关系是最大限度地提高过敏反应至关重要。两种类型的过敏原生物活性，即蛋白水解和肽脂/脂质结合，引发IgE和刺激对不相关过敏原的旁观者反应。大部分影响来自Toll样受体（TLR）4或TLR2信号传导，并且在蛋白酶过敏原的情况下，具有强烈疾病联系的额外血液效应的激活。相关兴趣是HDM过敏原与房屋粉尘基质的共同组分的相互作用，通过它们对过敏原或其自主调节免疫受体的含义。在此，我们提供了一种蛋白质溶解，脂质结合活性和与多糖和多糖分子识别系统的相互作用的当代视图，以及多糖分子识别系统协调底层过敏的主要反应。通过审查由基于结构的设计产生的新型抑制剂的疗效综述综述，证明了催化竞受群1 HDM蛋白酶过敏原组分的功率。

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