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The global incidence and prevalence of anaphylaxis in children in the general population: A systematic review

机译：一般人群中儿童过敏率的全球发病率和患病率：系统审查

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Background Despite an increasing number of publications from individual countries and regions, there is still no systematic review of the global epidemiology of anaphylaxis in the general paediatric population. Methods We conducted a systematic review, using a protocol registered and published with the international prospective register of systematic reviews (PROSPERO). Results were reported following PRISMA guidelines. The search strategy was designed in Medline (ovid) and modified for Embase (ovid) and PubMed. Papers were screened by two independent reviewers following selection and exclusion criteria. Data extraction and risk of bias assessment were completed by the same two reviewers. Studies in adults only or those that did not report data in children separately were excluded. Results A final total of 59 articles were included. Of these, 5 reported cumulative incidence, 39 reported incidence rate and 17 reported prevalence data. The incidence of anaphylaxis in children worldwide varied widely, ranging from 1 to 761 per 100 000 person-years for total anaphylaxis and 1 to 77 per 100 000 person-years for food-induced anaphylaxis. The definition of anaphylaxis from NIAID/FAAN was the most commonly used. Gender and ethnicity were demographic risk factors associated with anaphylaxis in children. Increasing total or food-induced anaphylaxis incidence over time was reported by 19 studies. Conclusion The reported incidence of anaphylaxis in children varied widely. Studies in developing countries are underrepresented. To accurately compare anaphylaxis incidence between countries and investigate the time trends, further studies using a standardized definition across different countries are required.
机译：背景，尽管各个国家和地区的出版物越来越多，但仍然没有对通用儿科人群的过敏反应流行病学的系统审查。方法使用注册和发布的议定书进行系统审查，并发布了国际临时登记册（Prospero）。结果据指引报告。搜索策略在Medline（Ovid）中设计，并修改了Embase（Ovid）和PubMed。在选择和排除标准之后，两个独立审稿人筛选论文。数据提取和偏见评估的风险由同一两个审稿人完成。仅排除了成年人的研究或没有报告儿童数据的人被排除在外。结果最终共有59篇文章。其中，5例报告累积发病率，39例报告发生率和17例普遍存在数据。全世界儿童的过敏反应性的发病率广泛多样化，从1至761人为每100 000人 - 总患者，每100 000人的1至77人诱导的食物诱导的过敏症。来自Niaid / Faan的过敏反应的定义是最常用的。性别和种族是与儿童过敏的人口危险因素。通过19项研究报告了随时间的总体或食物诱导的过敏性发病率。结论报告的儿童过敏性发病率差异很大。发展中国家的研究不足。为了准确比较国家之间的过敏反应发病率并调查时间趋势，需要在不同国家/地区使用标准化定义进行进一步的研究。

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