Optimal step doses for drug provocation tests to prove beta-lactam hypersensitivity

Chiriac A-M.; Rerkpattanapipat T.; Bousquet P-J; Molinari N.; Demoly P.

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Optimal step doses for drug provocation tests to prove beta-lactam hypersensitivity

机译：用于药物挑衅试验的最佳步骤剂量证明β-内酰胺超敏反应

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BackgroundDrug provocation tests (DPT) are commonly performed as part of -lactam (BL) allergy workup, in case of negative skin tests (ST) and in the absence of contraindications. The recommendations of learned societies have created a frame for DPT performance, but protocols vary widely between centres, generating various hypothesis-driven protocols (i.e. empirical dosing, driven by both safety concerns and practical aspects).

机译：背景技术挑衅试验（DPT）通常作为-ACTAM（BL）过敏处理的一部分，以防阴性皮肤测试（ST）和在没有禁忌症的情况下。学习社会的建议已经为DPT性能创造了框架，但在中心之间的协议范围内各种各样地变化，产生各种假设驱动的协议（即，通过安全问题和实践方面驱动的经验给药。

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来源
《Allergy》 |2017年第4期|共10页
作者
Chiriac A-M.; Rerkpattanapipat T.; Bousquet P-J; Molinari N.; Demoly P.;
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作者单位

Univ Hosp Montpellier Hop Arnaud de Villeneuve Dept Pulmonol Div Allergy Montpellier France;

Mahidol Univ Ramathibodi Hosp Fac Med Allergy Immunol &

Rheumatol Div Dept Med Bangkok Thailand;

Univ Hosp Montpellier Hop Arnaud de Villeneuve Dept Pulmonol Div Allergy Montpellier France;

Univ Hosp Montpellier Dept Clin Informat Clin Res Unit Montpellier France;

Univ Hosp Montpellier Hop Arnaud de Villeneuve Dept Pulmonol Div Allergy Montpellier France;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
-lactams; dose; drug hypersensitivity reaction; drug provocation test; survival analysis;

机译：-RACTAMS;剂量;药物超敏反应;药物挑衅试验;存活分析;

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专利

1. Optimal step doses for drug provocation tests to prove beta-lactam hypersensitivity [J] . Chiriac A-M., Rerkpattanapipat T., Bousquet P-J, Allergy . 2017,第4期

机译：用于药物挑衅试验的最佳步骤剂量证明β-内酰胺超敏反应
2. Drug-specific history, skin and in?vitro tests can reduce the need for drug provocation tests in betalactam-hypersensitivity [J] . Stefan W?hrl, Christian Ostermayer, Gabriele Sesztak-Greinecker, Allergology international: official journal of the Japanese Society of Allergology . 2021,第2期

机译：药物历史，皮肤和在β/ ce：斜体>试验可以减少βActam-endensitivity的药物挑衅试验的需要
3. Drug provocation tests in the diagnosis of hypersensitivity reactions to non-steroidal anti-inflammatory drugs in children. [J] . Maria A Zambonino, Maria J Torres, Candelaria Mu?oz, Pediatric allergy and immunology: official publication of the European Society of Pediatric Allergy and Immunology . 2013,第2期

机译：药物激发试验可诊断儿童对非甾体类抗炎药的超敏反应。
4. A New Model for Drug Interactions and Optimal Drug Dosing [C] . Zanderigo, E., Sartori, . 2005

机译：药物相互作用和最佳药物剂量的新模型
5. EXAMINATION OF THE DISCRIMINATIVE STIMULUS PROPERTIES OF MORPHINE: (A) DOSE 1, DOSE 2, SALINE DISCRIMINATION: A THREE CHOICE QUANTITATIVE DRUG DISCRIMINATION. (B) DRUG 1, DRUG 2, SALINE DISCRIMINATION: A THREE CHOICE QUALITATIVE DRUG DISCRIMINATION [D] . GAUVIN, DAVID VICTOR. 1987

机译：吗啡的区别刺激特性的检查：（A）剂量1，剂量2，盐水鉴别：三种选择的药物鉴别。（B）毒品1，毒品2，盐水歧视：三项定性毒品歧视
6. A practical method of drug provocation testing to prove tolerance to alternative drugs in drug hypersensitivity [O] . Ebru DAMADOĞLU, Özge ÖZTÜRK AKTAŞ, Gül KARAKAYA, 2021

机译：一种实用的药物挑衅测试方法以证明对药物超敏反应中的替代药物的耐受性
7. Short and extended provocation tests have similar negative predictive value in non-immediate hypersensitivity to beta-lactams in children [O] . F.S. Regateiro, I. Rezende, N. Pinto, 2019

机译：短期和扩展的挑衅试验在儿童中对β-内酰胺的非直接超敏反应性相似的负面预测值

Optimal step doses for drug provocation tests to prove beta-lactam hypersensitivity

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