Targeting granulocyte-macrophage colony-stimulating factor in epithelial and vascular remodeling in experimental eosinophilic esophagitis

McNamee E. N.; Biette K. A.; Hammer J.; Harris R.; Miyazawa H.; Lee J. J.; Furuta G. T.; Masterson J. C.

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Targeting granulocyte-macrophage colony-stimulating factor in epithelial and vascular remodeling in experimental eosinophilic esophagitis

机译：实验性嗜酸性食道炎上皮和血管重塑中靶向粒细胞 - 巨噬细胞菌刺激因子

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Background: Eosinophilic esophagitis (EoE) is a chronic antigen-mediated clinicopathologic disease of the esophagus characterized by an eosinophil-predominant inflammatory infiltrate. A clinical hallmark is extensive tissue remodeling including basal zone hyperplasia, fibrosis, and angiogenesis. However, the cellular mechanisms responsible for these processes are not fully defined. We hypothesized that targeting granulocyte-macrophage colony-stimulating factor (GM-CSF; an agonist cytokine linked with eosinophil survival and activation) would be protective in a preclinical model of EoE.

机译：背景：嗜酸性食道炎（EOE）是一种慢性抗原介导的食道临床病理学疾病，其特征是嗜酸性粒细胞主要炎性浸润。临床标志是广泛的组织重塑，包括基础区域增生，纤维化和血管生成。但是，不完全定义负责这些过程的蜂窝机制。我们假设靶向粒细胞 - 巨噬细胞殖民地刺激因子（GM-CSF;与嗜酸性粒细胞存活和激活相关的激动剂细胞因子）将在EOE的临床前模型中保护。

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来源
《Allergy》 |2017年第8期|共11页
作者
McNamee E. N.; Biette K. A.; Hammer J.; Harris R.; Miyazawa H.; Lee J. J.; Furuta G. T.; Masterson J. C.;
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作者单位

Univ Colorado Sect Pediat Gastroenterol Hepatol &

Nutr Gastrointestinal Eosinophil Dis Program;

Univ Colorado Sect Pediat Gastroenterol Hepatol &

Nutr Gastrointestinal Eosinophil Dis Program;

Univ Colorado Sect Pediat Gastroenterol Hepatol &

Nutr Gastrointestinal Eosinophil Dis Program;

Univ Colorado Sect Pediat Gastroenterol Hepatol &

Nutr Gastrointestinal Eosinophil Dis Program;

Univ Colorado Sect Pediat Gastroenterol Hepatol &

Nutr Gastrointestinal Eosinophil Dis Program;

Mayo Clin Dept Biochem &

Mol Biol Scottsdale AZ USA;

Univ Colorado Sect Pediat Gastroenterol Hepatol &

Nutr Gastrointestinal Eosinophil Dis Program;

Univ Colorado Sect Pediat Gastroenterol Hepatol &

Nutr Gastrointestinal Eosinophil Dis Program;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
eosinophil; epithelial; esophagitis; granulocyte-macrophage colony-stimulating factor (GM-CSF); GM-CSF receptor;

机译：嗜酸性粒细胞;上皮;食管炎;粒细胞 - 巨噬细胞菌落刺激因子（GM-CSF）;GM-CSF受体;

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专利

1. Targeting granulocyte-macrophage colony-stimulating factor in epithelial and vascular remodeling in experimental eosinophilic esophagitis [J] . McNamee E. N., Biette K. A., Hammer J., Allergy . 2017,第8期

机译：实验性嗜酸性食道炎上皮和血管重塑中靶向粒细胞 - 巨噬细胞菌刺激因子
2. Targeting AMCase reduces esophageal eosinophilic inflammation and remodeling in a mouse model of egg induced eosinophilic esophagitis [J] . ChoJ.Y., RosenthalP., MillerM., International immunopharmacology . 2014,第1期

机译：靶向AMCase可减轻鸡蛋诱发的嗜酸性食管炎小鼠模型中的食道嗜酸性粒细胞炎症和重塑
3. Granulocyte-macrophage colony-stimulating factor inhalation therapy for patients with idiopathic pulmonary alveolar proteinosis: a pilot study; and long-term treatment with aerosolized granulocyte-macrophage colony-stimulating factor: a case report. [J] . Tazawa R, Nakata K, Inoue Y, Respirology : . 2006,第Suppla1期

机译：特发性肺泡蛋白沉着症患者吸入粒细胞巨噬细胞集落刺激因子吸入疗法雾化的粒细胞巨噬细胞集落刺激因子长期治疗：1例。
4. Conjugation of High-Molecular Weight Poly(ethylene glycol) to Cytokines: Granulocyte-Macrophage Colony-Stimulating Factors as Model Substrates [C] . Merry R.Sherman, L.David Williams, Mark G.P.Saifer, Poly(ethylene glycol) : Chemistry and biological applications . 1997

机译：高分子量聚乙二醇与细胞因子的缀合：粒细胞-巨噬细胞集落刺激因子作为模型基质。
5. Colony-Stimulating Factor-1 Receptor Inhibition Reverses the Vascular Leakage that Causes Malignant Ascites in Late-Stage Epithelial Ovarian Cancer [D] . Moughon, Diana Louise 2015

机译：集落刺激因子-1受体抑制逆转导致晚期上皮性卵巢癌的恶性腹水的血管渗漏。
6. Thrombin Stimulates Synthesis of Macrophage Colony-Stimulating Factor Granulocyte-Macrophage Colony-Stimulating Factor and Granulocyte Colony-Stimulating Factor by Human Proximal Tubular Epithelial Cells in Culture [O] . Yuko Shimaya, Michiko Shimada, Yoshiko Shutto, 2012

机译：凝血酶通过培养人近端肾小管上皮细胞刺激巨噬细胞集落刺激因子粒细胞-巨噬细胞集落刺激因子和粒细胞集落刺激因子的合成。
7. Targeting granulocyte-macrophage colony-stimulating factor in epithelial and vascular remodeling in experimental eosinophilic esophagitis [O] . E. N. McNamee, K. A. Biette, J. Hammer, 2017

机译：靶向粒细胞 - 巨噬细胞群刺激因子在实验性嗜酸性食管炎中上皮和血管重塑中的刺激因子
8. Interdependence of the Radioprotective Effects of Human Recombinant Interleukin 1alpha, Tumor Necrosis Factor alpha, Granulocyte Colony-Stimulating Factor, and Murine Recombinant Granulocyte-Macrophage Colony-Stimulating Factor [R] . Neta, R., Oppenheim, J. J., Douches, S. D. 1988

机译：人重组白细胞介素1α，肿瘤坏死因子α，粒细胞集落刺激因子和小鼠重组粒细胞 - 巨噬细胞集落刺激因子的辐射保护作用的相互依赖性

Targeting granulocyte-macrophage colony-stimulating factor in epithelial and vascular remodeling in experimental eosinophilic esophagitis

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