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首页> 外文期刊>Allergy >Biomarkers for monitoring clinical efficacy of allergen immunotherapy for allergic rhinoconjunctivitis and allergic asthma: an EAACI Position Paper
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Biomarkers for monitoring clinical efficacy of allergen immunotherapy for allergic rhinoconjunctivitis and allergic asthma: an EAACI Position Paper

机译:用于监测过敏原免疫疗法对过敏性鼻咽炎和过敏性哮喘的临床疗效的生物标志物:EACI定位纸

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摘要

Background: Allergen immunotherapy (AIT) is an effective treatment for allergic rhinoconjunctivitis (AR) with or without asthma. It is important to note that due to the complex interaction between patient, allergy triggers, symptomatology and vaccines used for AIT, some patients do not respond optimally to the treatment. Furthermore, there are no validated or generally accepted candidate biomarkers that are predictive of the clinical response to AIT. Clinical management of patients receiving AIT and efficacy in randomised controlled trials for drug development could be enhanced by predictive biomarkers.
机译:背景:过敏原免疫疗法(AIT)是对具有或没有哮喘的过敏性鼻咽炎(AR)的有效治疗方法。 重要的是要注意,由于患者之间的复杂相互作用,过敏触发器,症状,症状,用于AIT的疫苗,一些患者没有对治疗的最佳反应。 此外,没有验证或通常接受的候选生物标志物,其是对AIT的临床反应预测。 通过预测的生物标志物可以提高接受药物开发的随机对照试验的AIT和功效患者的临床管理。

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  • 来源
    《Allergy》 |2017年第8期|共18页
  • 作者单位

    Imperial Coll London Natl Heart &

    Lung Inst Allergy &

    Clin Immunol London England;

    Imperial Coll London Natl Heart &

    Lung Inst Allergy &

    Clin Immunol London England;

    Univ Zurich Swiss Inst Allergy &

    Asthma Res SIAF Davos Switzerland;

    Med Univ Vienna Ctr Pathophysiol Infectiol &

    Immunol Dept Pathophysiol &

    Allergy Res Vienna;

    Univ Med Ctr Utrecht Dept Immunol &

    Dermatol Utrecht Netherlands;

    Ackermann &

    Kleine Tebbe Outpatient Clin Allergy &

    Asthma Ctr Westend Berlin Germany;

    Med Univ Vienna Dept Pathophysiol &

    Allergy Res Vienna Austria;

    Tech Univ Ctr Allergy &

    Environm ZAUM Munich Germany;

    Kings Coll London Div Asthma Allergy &

    Lung Biol London England;

    Med Univ Vienna Ctr Pathophysiol Infectiol &

    Immunol Dept Pathophysiol &

    Allergy Res Div;

    Copenhagen Univ Hosp Gentofte Allergy Clin Copenhagen Denmark;

    Imperial Coll London Natl Heart &

    Lung Inst Allergy &

    Clin Immunol London England;

    Univ Hosp Montpellier Arnaud Villeneuve Hosp Dept Pulmonol Div Allergy Paris France;

    Heidelberg Univ Med Fac Mannheim Univ Med Mannheim Dept Otorhinolaryngol Head &

    Neck Surg;

    Allergy Learning &

    Consulting Copenhagen Denmark;

    Imperial Coll London Natl Heart &

    Lung Inst Allergy &

    Clin Immunol London England;

    Tech Univ Klinikum Rechts Isar Allergy Sect Dept Otolaryngol Munich Germany;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    allergen immunotherapy; basophil activation; biomarkers; IgE-FAB; IgG4;

    机译:过敏原免疫疗法;嗜碱性激活;生物标志物;IgE-Fab;IgG4;

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