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首页> 外文期刊>Allergy >Therapeutic effect of capsaicin nasal treatment in patients with mixed rhinitis unresponsive to intranasal steroids
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Therapeutic effect of capsaicin nasal treatment in patients with mixed rhinitis unresponsive to intranasal steroids

机译：辣椒素鼻腔治疗在混合鼻炎对鼻内类固醇的患者中的治疗效果

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Abstract Literature is convincing regarding the efficacy of capsaicin nasal treatment in idiopathic rhinitis (IR). However, up to 50% of IR patients do not meet the strict inclusion criteria of the trials conducted so far. As a consequence, the efficacy of capsaicin is unknown in a significant number of IR patients that do not meet the strict inclusion/exclusion criteria (J Allergy Clin Immunol. 2014;133:1332, J Allergy Clin Immunol. 2017; [Epub ahead of print]). “Mixed rhinitis” (MR) patients have more than one major etiologic factor involved in the mucosal pathology. We have no idea about the efficacy of capsaicin nasal spray in these patients nor about the time interval to seek a second application. We report here that capsaicin nasal spray is effective in a broader group of IR than the purely selected ones described before, that subjective nasal hyper‐reactivity is a good predictor of positive outcome, and that the time interval for seeking a second treatment is likely to be shorter in MR patients than in the strictly selected IR patients.
机译：摘要文学令人信服，关于辣椒素鼻腔治疗在特发性鼻炎（IR）中的疗效。然而，高达50％的IR患者不符合到目前为止所进行的严格纳入标准。因此，辣椒素的疗效在不符合严格的包容/排除标准的大量IR患者中未知（J Allergy Clin Immunol.2014; 133：1332，J Allery Clin Immunol。2017; [Epub前面打印]）。 “混合鼻炎”（MR）患者有多于一个粘膜病理学的主要病因因素。我们对这些患者中辣椒素鼻腔喷雾的疗效也不是寻求第二次申请的时间间隔。我们在此报告，辣椒素鼻喷雾在更广泛的IR中有效而不是之前所描述的纯粹选择的IR，那个主观鼻超反应性是积极结果的良好预测因子，并且寻求第二次治疗的时间间隔很可能先生患者比在严格选择的IR患者中更短。

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