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首页> 外文期刊>Allergy >Is the atopic march related to confounding by genetics and early‐life environment? A systematic review of sibship and twin data
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Is the atopic march related to confounding by genetics and early‐life environment? A systematic review of sibship and twin data

机译：Atopic 3月是遗传和早期环境的混淆有关吗？ Sibship和双数据的系统审查

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摘要

Abstract A popular hypothesis known as the atopic march proposes a set of sequential allergy and respiratory disorders in early childhood contributes enormously to the burden of disease in developed countries. Although the concept of the atopic march has been refined and strengthened by many cross‐sectional and longitudinal studies linking eczema as the initial manifestation with progression to hay fever and then asthma, there is yet no definitive proof that the atopic march is the primary causal factor in childhood allergic disease. This debate is mainly related to the controversy around potential confounding of these associations by genetic and environmental factors. Family studies are ideally suited to unravelling the role of these factors. While multiple reviews have synthesized evidence from studies investigating this question, no review to date has explored specific evidence generated by twin and sibling studies to understand the aetiology of atopic march diseases. Our aim was to conduct a systematic review of twin and sibling studies that examine the allergic phenotypes that form the atopic march, to determine whether such analyses of data from these studies attempt to control for the effect confounding by shared factors, and to report estimates of the magnitude of associations between multiple phenotypes. Our review suggests that (1) genetics play a bigger role predisposing eczema to hay fever and eczema to asthma than environmental factors, and (2) the link between eczema and asthma and hay fever is independent of shared early‐life environmental factors.
机译：摘要众所周知，众所周知的假设提出了一系列童年的序贯过敏和呼吸系统疾病促进了发达国家疾病的负担。虽然基息3月的概念被诸多横断面和纵向研究的概念，但许多横断面和纵向研究将湿疹链接为初步表现，初步表现在患有花粉热和哮喘的哮喘，但尚未证明Atopic 3月是主要因果因素在儿童过敏性疾病中。这种辩论主要与遗传和环境因素对这些关联的潜在混淆争议有关。家庭研究非常适合解开这些因素的作用。虽然多次评论有来自研究的综合证据调查了这个问题，但迄今没有审查迄今探讨了双胞胎和兄弟姐妹研究产生的具体证据，以了解特征3月疾病的病毒学。我们的目的是对双胞胎和兄弟姐妹进行的系统审查，检查形成特征3月的过敏表型，以确定这些研究的数据是否试图通过共享因素来控制效果混淆，并报告估计多种表型之间的关联程度。我们的评论表明，（1）遗传学在比环境因素临近湿疹与哮喘的湿热和湿疹的遗传性比环境因素更大，而（2）湿疹和哮喘和干草发烧的联系与共同的早期环境因素无关。

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  • 来源
    《Allergy》 |2018年第1期|共12页
  • 作者

    Khan S. J.; Dharmage S. C.; Matheson M. C.; Gurrin L. C.;

  • 作者单位

    Centre for Epidemiology and BiostatisticsThe University of MelbourneMelbourne Vic Australia;

    Centre for Epidemiology and BiostatisticsThe University of MelbourneMelbourne Vic Australia;

    Centre for Epidemiology and BiostatisticsThe University of MelbourneMelbourne Vic Australia;

    Centre for Epidemiology and BiostatisticsThe University of MelbourneMelbourne Vic Australia;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    asthma; atopic march; eczema; hay fever; twin study;

    机译：哮喘;特征3月;湿疹;花粉发烧;双胞胎研究;

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