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Asthma in the elderly and late-onset adult asthma

机译：老年人和晚期成人哮喘的哮喘

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Elderly asthmatics are at a higher risk for morbidity and mortality from their asthma than younger patients. There are important age-related physiologic and immunologic changes that complicate the presentation, diagnosis, and management of asthma in the aged population. Evidence suggests that elderly asthmatics are more likely to be underdiagnosed and undertreated. Additionally, elderly patients with asthma have highest rates of morbidity and mortality from their disease than younger patients. The underlying airway inflammation of asthma in this age group likely differs from younger patients and is felt to be non-type 2 mediated. While elderly patients are underrepresented in clinical trials, subgroup analysis of large clinical trials suggests they may be less likely to respond to traditional asthma therapies (ie, corticosteroids). As the armamentarium of pharmacologic asthma therapies expands, it will be critical to include elderly asthmatics in large clinical trials so that therapy may be better tailored to this at-risk and growing population.
机译：老年哮喘的发病率和哮喘患者的风险较高，而不是年轻患者。有重要的年龄相关的生理和免疫变化，使哮喘的介绍，诊断和管理复杂化。证据表明，老年哮喘学更可能被诊断和患病。此外，哮喘的老年患者与他们的疾病的发病率和死亡率高于年轻患者。在该年龄组中哮喘的潜水道炎症可能与年轻患者不同，并且被含有非型2患者。虽然老年患者在临床试验中表达出代表性，但大型临床试验的亚组分析表明它们可能不太可能反应传统的哮喘疗法（即皮质类固醇）。随着药理学哮喘疗法的武器膨胀，在大型临床试验中包括老年哮喘是至关重要的，因此可以更好地根据这种风险和不断增长的人群量身定制治疗。

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