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首页> 外文期刊>Allergy >RItA: The Italian severe/uncontrolled asthma registry
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RItA: The Italian severe/uncontrolled asthma registry

机译：丽塔：意大利严重/不受控制的哮喘登记处

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Abstract Background The Italian severe/uncontrolled asthma ( SUA ) web‐based registry encompasses demographic, clinical, functional, and inflammatory data; it aims to raise SUA awareness, identifying specific phenotypes and promoting optimal care. Methods Four hundred and ninety three adult patients from 27 Italian centers (recruited in 2011‐2014) were analyzed. Results Mean age was 53.8?years. SUA patients were more frequently female (60.6%), with allergic asthma (83.1%). About 30% showed late onset of asthma diagnosis/symptoms (40?years); the mean age for asthma symptoms onset was 30.2?years and for asthma diagnosis 34.4?years. 97.1% used ICS (dose 2000 BDP ), 93.6% LABA in association with ICS , 53.3% LTRA s, 64.1% anti‐IgE, 10.7% theophylline, and 16.0% oral corticosteroids. Mean FEV 1 % pred of 75.1%, median values of 300/mm 3 of blood eosinophil count, 323? kU /L of serum total IgE, and 24?ppb of FENO were shown. Most common comorbidities were allergic rhinitis (62.4%), gastroesophageal reflux (42.1%), sinusitis (37.9%), nasal polyposis (30.2%), and allergic conjunctivitis (30.2%). 55.7% of SUA patients had exacerbations in the last 12?months, 9.7% emergency department visits, and 7.3% hospitalizations. Factors associated with exacerbation risk were obesity ( OR , 95% CI 2.46, 1.11‐5.41), psychic disorders (2.87, 0.89‐9.30—borderline), nasal polyps (1.86, 0.88‐3.89—borderline), partial/poor asthma treatment adherence (2.54, 0.97‐6.67—borderline), and anti‐IgE use in a protective way (0.26, 0.12‐0.53). Comparisons to severe asthma multicenter studies and available registries showed data consistency across European and American populations. Conclusions An international effort in the implementation of SUA patients’ registries could help to better understand the clinical features and to manage severe asthma, representing a non‐negligible socioeconomic burden for health services.
机译：摘要背景意大利严重/不受控制的哮喘（SUA）基于Web的注册表包括人口统计，临床，功能和炎症数据;它旨在提高SUA意识，鉴定特异性表型并促进最佳护理。方法分析了来自27个意大利中心的四百九十三名成年患者（2011 - 2011年招聘）。结果平均年龄为53.8？年龄。 SUA患者更频繁的雌性（60.6％），过敏性哮喘（83.1％）。大约30％显示哮喘诊断/症状的晚期发病（＆ 40？年）;哮喘症状发病的平均年龄为30.2岁，哮喘诊断为34.4岁。 97.1％二手​​IC（剂量2000 BDP），与IC相关的93.6％Laba，53.3％LTRA S，64.1％抗IgE，10.7％茶碱和16.0％口服皮质类固醇。平均fev 1％pred为75.1％，中值300 / mm 3的血液粒细胞计数，323？显示了Ku / L总IgE和24？PPB的FENO。大多数常见的合并症是过敏性鼻炎（62.4％），胃食管反流（42.1％），鼻窦炎（37.9％），鼻息蛋白（30.2％）和过敏性结膜炎（30.2％）。 55.7％的SUA患者在过去的12个月中发生了恶化，9.7％的急诊部门访问和7.3％的住院治疗。与加剧风险相关的因素是肥胖症（或95％CI 2.46,1.11-5.41），心理障碍（2.87,0.89-9.30-边界），鼻息肉（1.86,0.88-3.89-边界线），部分/贫困哮喘治疗遵守（2.54,0.97-6.67-边界线），防氏采用保护方式（0.26,0.12-0.53）。严重哮喘多中心研究和可用注册管理机构的比较显示欧美人民的数据一致性。结论实施SUA患者注册管理机构的国际努力有助于更好地了解临床特征和管理严重的哮喘，代表卫生服务的不可忽视的社会经济负担。

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