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首页> 外文期刊>Allergy >The sex‐shift in single disease and multimorbid asthma and rhinitis during puberty ‐ a study by MeDALL
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The sex‐shift in single disease and multimorbid asthma and rhinitis during puberty ‐ a study by MeDALL

机译：青春期单一疾病和多压表哮喘和鼻炎的性别转移 - 由Medall的研究

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摘要

Abstract Background Cross‐sectional studies suggested that allergy prevalence in childhood is higher in boys compared to girls, but it remains unclear whether this inequality changes after puberty. We examined the sex‐specific prevalence of asthma and rhinitis as single and as multimorbid diseases before and after puberty onset in longitudinal cohort data. Methods In six European population‐based birth cohorts of MeDALL, we assessed the outcomes: current rhinitis, current asthma, current allergic multimorbidity (ie, concurrent asthma and rhinitis), puberty status and allergic sensitization by specific serum antibodies (immunoglobulin E) against aero‐allergens. With generalized estimating equations, we analysed the effects of sex, age, puberty (yes/no) and possible confounders on the prevalence of asthma and rhinitis, and allergic multimorbidity in each cohort separately and performed individual participant data meta‐analysis. Findings We included data from 19?013 participants from birth to age 14‐20?years. Current rhinitis only affected girls less often than boys before and after puberty onset: adjusted odds ratio for females vs males 0.79 (95%‐confidence interval 0.73‐0.86) and 0.86 (0.79‐0.94), respectively (sex‐puberty interaction P ?=?.089). Similarly, for current asthma only, females were less often affected than boys both before and after puberty onset: 0.71, 0.63‐0.81 and 0.81, 0.64‐1.02, respectively (sex‐puberty interaction P ?=?.327). The prevalence of allergic multimorbidity showed the strongest sex effect before puberty onset (female‐male‐OR 0.55, 0.46‐0.64) and a considerable shift towards a sex‐balanced prevalence after puberty onset (0.89, 0.74‐1.04); sex‐puberty interaction: P ??.001. Interpretation The male predominance in prevalence before puberty and the “sex‐shift” towards females after puberty onset were strongest in multimorbid patients who had asthma and rhinitis concurrently.
机译：摘要背景横断面研究表明，与女孩相比，男孩的过敏率较高，但仍然不清楚这种不平等是否在青春期后变化。我们检查了纵向队列中青春期发作前后的单身哮喘和鼻炎的性别特异性哮喘和鼻炎疾病。方法在六种欧洲人口的出生队列的次数中，我们评估了结果：目前的鼻炎，目前哮喘，目前过敏多药（即，同时哮喘和鼻炎），Puerty血清抗体（免疫球蛋白E）对Aero的特异性血清抗体（免疫球蛋白E）的过敏性致敏-Allergens。通过广义估计方程，我们分析了性别，年龄，青春期（是/否）和可能的混淆对哮喘和鼻炎的患病率的影响，以及分别进行各个队列的过敏多重性，并进行各个参与者数据META分析。调查结果我们包括来自19岁的19岁的数据（013年从出生到14-20岁）？年。目前的鼻炎仅仅受到青春期前后的男孩的影响：女性的调整赔率比分别为0.79（95％-95％ - 8.86）和0.86（0.79-0.94）（Sex-Puberty Interaction P？= ？.089）。同样，对于目前的哮喘仅，女性常见于青春期前后的男孩效果较小：0.71,0.63-0.81和0.81，0.64-1.02分别（性青春期相互作用P？= 327）。过敏多重无水性的患病率显示出青春期发作前（雌性 - 男性 - 或0.55,0.46-0.64）的性能最强的性别效应，并且在青春期发作后朝着性别平衡患病率（0.89,0.74-1.04）相当大的转变;性欲青春期相互作用：p？＆？。001。解释在青春期前青春期前的普遍存在的男性优势，在青春期发作后对女性的“性感转移”对患有哮喘和鼻炎的多功能性患者最强。

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  • 来源
    《Allergy》 |2018年第3期|共13页
  • 作者

    Keller T.; Hohmann C.; Standl M.; Wijga A. H.; Gehring U.; Melén E.; Almqvist C.; Lau S.; Eller E.; Wahn U.; Christiansen E. S.; von Berg A.; Heinrich J.; Lehmann I.; Maier D.; Postma D. S.; Antó J. M.; Bousquet J.; Keil T.; Roll S.;

  • 作者单位

    Institute of Social Medicine Epidemiology and Health EconomicsCharité – Universit?tsmedizin;

    Institute of Social Medicine Epidemiology and Health EconomicsCharité – Universit?tsmedizin;

    Institute of Epidemiology IHelmholtz Zentrum München ‐ German Research Center for Environmental;

    Center for Nutrition Prevention and Health ServicesNational Institute for Public Health and the;

    Division of Environmental EpidemiologyUtrecht UniversityUtrecht The Netherlands;

    Department of Medical Epidemiology and BiostatisticsKarolinska InstitutetSolna Sweden;

    Department of Medical Epidemiology and BiostatisticsKarolinska InstitutetSolna Sweden;

    Department of Paediatric Pneumology &

    ImmunologyCharité‐Universit?tsmedizin BerlinBerlin Germany;

    Department of Dermatology and Allergy CenterOdense University HospitalOdense Denmark;

    Department of Paediatric Pneumology &

    ImmunologyCharité‐Universit?tsmedizin BerlinBerlin Germany;

    Department of Dermatology and Allergy CenterOdense University HospitalOdense Denmark;

    Department of PediatricsResearch InstituteWesel Germany;

    Institute of Epidemiology IHelmholtz Zentrum München ‐ German Research Center for Environmental;

    Department of Environmental Immunology/Core Facility StudiesHelmholtz Centre for Environmental;

    Biomax Informatics AGMunich Germany;

    Department of PulmonologyUniversity of GroningenGroningen The Netherlands;

    Centre for Research in Environmental Epidemiology (CREAL)ISGlobalBarcelona Spain;

    Universitat Popmpeu Fabra (UPF)Barcelona Spain;

    Institute of Social Medicine Epidemiology and Health EconomicsCharité – Universit?tsmedizin;

    Institute of Social Medicine Epidemiology and Health EconomicsCharité – Universit?tsmedizin;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    allergic multimorbidity; asthma; birth cohort; puberty; rhinitis;

    机译：过敏多药物;哮喘;出生队列;青春期;鼻炎;

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