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Maternal hypothyroidism in the perinatal period and childhood asthma in the offspring

机译：在后代围产期时期的母体甲状腺功能亢进症和儿童哮喘

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Abstract Background There is increasing interest in the possible link between maternal hypothyroidism in the perinatal period and childhood asthma risk. We explored this in this study while accounting for the timing of hypothyroidism diagnosis. Further, we evaluated whether the risk was moderated by thyroid hormone treatment during pregnancy. Methods We conducted a population‐based cohort study using Danish national registers. All live‐born singletons in Denmark from 1998 to 2007 were identified. Maternal hypothyroidism and asthma in the children were defined by data from the Patient Register and Prescription Registry. We estimated incidence rate ratios ( IRR s) of asthma among children born to hypothyroid mothers versus children born to mothers with no recorded thyroid dysfunction using Poisson regression models. Results Of 595 669 children, 3524 children were born to mothers with hypothyroidism diagnosed before delivery and 4664 diagnosed after delivery. Overall, 48 990 children received treatment for asthma. The IRR s of asthma was 1.16 (95% confidence interval ( CI ): 1.03‐1.30) and 1.12 (95% CI : 1.02‐1.24) for children born to mothers with hypothyroidism diagnosed before and after delivery, compared to children born to mothers with no thyroid dysfunction. The highest risk was observed among children born to mothers with hypothyroidism diagnosed before delivery who did not receive thyroid hormone treatment during pregnancy ( IRR =1.37, 95% CI : 1.04‐1.80). Conclusion Our findings suggest that maternal hypothyroidism, especially when it is untreated, increases childhood asthma risk. Early detection and appropriate treatment of hypothyroidism in pregnant women may be an area for possible prevention of childhood asthma.
机译：摘要背景越来越兴趣在围产期时期和儿童哮喘风险中母体甲状腺功能减退之间的可能链接。我们在这项研究中探讨了这一点，同时核算了甲状腺功能亢进诊断的时间。此外，我们评估了妊娠期间甲状腺激素治疗的风险是否受到调节。方法采用丹麦国家寄存器进行了一项基于人口的队列研究。从1998年到2007年丹麦的所有在丹麦的所有活出生的单身都得到了确定。儿童的母体甲状腺功能减退症和哮喘由患者登记册和处方注册处的数据定义。我们估计哮喘发病率的哮喘发病率比（Irrs），令人满意的母亲与母亲出生于母亲的母亲，没有录制的甲状腺功能障碍使用泊松回归模型。结果595 669名儿童，3524名儿童为母亲诞生于母亲，甲状腺功能减退症诊断，递送后4664次诊断。总体而言，48 990名儿童接受了哮喘治疗。哮喘的哮喘患者为1.16（95％置信区间（CI）：1.03-1.30）和1.12（95％CI：1.02-1.24），儿童为母亲出生于甲状腺功能亢进的患者，与母亲出生于母亲之前和交付前后没有甲状腺功能障碍。在患有甲状腺功能亢进的母亲之前观察到最高风险，甲状腺功能减退症患者在妊娠期间没有接受甲状腺激素治疗（IRR = 1.37,95％CI：1.04-1.80）。结论我们的研究结果表明，孕产妇甲状腺功能减退症，特别是当它未经处理时，增加儿童哮喘风险。早期检测和适当治疗孕妇甲状腺功能亢进症可能是可能预防儿童哮喘的一个区域。

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  • 来源
    《Allergy》 |2018年第4期|共8页
  • 作者

    Liu X.; Andersen S. L.; Olsen J.; Agerbo E.; Schlünssen V.; Dharmage S. C.; Munk‐Olsen T.;

  • 作者单位

    The National Center for Register‐based ResearchAarhus UniversityAarhus Denmark;

    Department of EndocrinologyAalborg University HospitalAalborg Denmark;

    Department of Clinical EpidemiologyAarhus University HospitalAarhus Denmark;

    The National Center for Register‐based ResearchAarhus UniversityAarhus Denmark;

    Section for Environmental Occupational and HealthAarhus UniversityAarhus Denmark;

    Allergy and Lung Health UnitUniversity of MelbourneMelbourne VIC Australia;

    The National Center for Register‐based ResearchAarhus UniversityAarhus Denmark;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    asthma; childhood; cohort study; hypothyroidism; perinatal;

    机译：哮喘;童年;队列研究;甲状腺功能减退症;围产期;

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