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Innate immunity in allergy

机译：过敏的先天免疫

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Abstract Innate immune system quickly responds to invasion of microbes and foreign substances through the extracellular and intracellular sensing receptors, which recognize distinctive molecular and structural patterns. The recognition of innate immune receptors leads to the induction of inflammatory and adaptive immune responses by activating downstream signaling pathways. Allergy is an immune‐related disease and results from a hypersensitive immune response to harmless substances in the environment. However, less is known about the activation of innate immunity during exposure to allergens. New insights into the innate immune system by sensors and their signaling cascades provide us with more important clues and a framework for understanding allergy disorders. In this review, we will focus on recent advances in the innate immune sensing system.
机译：摘要先天免疫系统通过细胞外和细胞内传感受体迅速响应微生物和异物的侵袭，识别独特的分子和结构图案。 识别先天免疫受体导致通过激活下游信号传导途径诱导炎症和适应性免疫应答。 过敏性是一种免疫相关疾病，对环境过敏的免疫反应产生了对环境中无害物质的结果。 然而，关于暴露于过敏原期间先天免疫的激活较少。 通过传感器及其信号级联进入先天免疫系统的新见解为我们提供了更重要的线索和理解过敏障碍的框架。 在本综述中，我们将重点关注天生免疫传感系统的最新进展。

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