Antibiotic use during pregnancy increases offspring asthma severity in a dose-dependent manner

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Antibiotic use during pregnancy increases offspring asthma severity in a dose-dependent manner

机译：怀孕期间的抗生素使用增加了以剂量依赖的方式增加了哮喘严重程度

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Background: The use of antibiotics during pregnancy is associated with increased allergic asthma risk in the offspring, and given that approximately 25% of pregnant women are prescribed antibiotics, it is important to understand the mechanisms contributing to this phenomenon. Currently, there are no studies that directly test this association experimentally. Our objective was to develop a mouse model in which antibiotic treatment during pregnancy results in increased offspring asthma susceptibility.

机译：背景：在怀孕期间使用抗生素与后代的过敏性哮喘风险增加有关，并且鉴于大约25％的孕妇是处方抗生素，了解对这种现象的机制有助于这种现象。目前，没有研究实验直接测试这一协会。我们的目的是开发一种小鼠模型，其中妊娠期间的抗生素治疗导致哮喘的后代哮喘易感性增加。

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《Allergy》 |2020年第8期|共12页
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正文语种 eng
中图分类医学免疫学;
关键词
antibiotics; asthma; microbiome; pregnancy; short-chain fatty acid;

机译：抗生素;哮喘;微生物组;妊娠;短链脂肪酸;

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专利

1. Antibiotic use during pregnancy increases offspring asthma severity in a dose-dependent manner [J] . Allergy . 2020,第8期

机译：怀孕期间的抗生素使用增加了以剂量依赖的方式增加了哮喘严重程度
2. Control and severity of asthma during pregnancy are associated with asthma incidence in offspring: two-stage case–control study [J] . A. Forget, é. Rey, J-L. Malo, The European respiratory journal : . 2009,第3期

机译：妊娠期间哮喘的控制和严重程度与后代的哮喘发生率相关：两阶段病例对照研究
3. Maternal house dust mite exposure during pregnancy enhances severity of house dust mite–induced asthma in murine offspring [J] . Phoebe K. Richgels, Amnah Yamani, Claire A. Chougnet, The Journal of Allergy and Clinical Immunology . 2017,第5期

机译：孕产妇尘螨暴露在怀孕期间增强了House粉尘螨诱导的小鼠后代哮喘的严重程度
4. Fluid flow increases mineralized matrix deposition in three-dimensional perfusion culture of marrow stromal osteoblasts in a dose-dependent manner [C] . Sikavitsas, V.I., Bancroft, . 2002

机译：流体流量以剂量依赖性方式增加了骨髓基质成骨细胞的三维灌注培养中矿化基质的沉积
5. Antibiotic Use During Pregnancy and Neurodevelopmental Outcomes of Offspring in Early Childhood [D] . Gamache, Tressa. 2020

机译：幼儿期间怀孕和神经发育成果的抗生素使用
6. Maternal house dust mite exposure during pregnancy enhances severity of HDM-induced asthma in murine offspring [O] . Phoebe K. Richgels, Amnah Yamani, Claire A. Chougnet, -1

机译：孕期母婴尘螨暴露会增加HDM诱导的鼠后代哮喘的严重性
7. Antibiotic use during pregnancy increases offspring asthma severity in a dose‐dependent manner [O] . Moumen M. Alhasan, Alissa M. Cait, Markus M. Heimesaat, 2020

机译：妊娠期间的抗生素使用增加了以剂量依赖的方式增加了哮喘严重程度

Antibiotic use during pregnancy increases offspring asthma severity in a dose-dependent manner

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