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首页> 外文期刊>Allergy >Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)‐induced epithelial cytokine release through aryl hydrocarbon receptor in asthma
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Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)‐induced epithelial cytokine release through aryl hydrocarbon receptor in asthma

机译：苯并（a）芘促进皮肤科第1组（der f 1） - 抑制通过哮喘中的芳基烃受体的上皮细胞因子释放

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Abstract Background Environmental pollutants, which coexist with allergens, have been associated with the exacerbation of asthma. However, the underlying molecular mechanisms remain elusive. We sought to determine whether benzo(a)pyrene (BaP) co‐exposure with dermatophagoides group?1?allergen (Der f 1) can potentiate Der f 1‐induced asthma and its underlying mechanisms. Methods The effect of BaP was investigated in Der f 1‐induced mouse model of asthma, including airway hyper‐responsiveness, allergic inflammation, and epithelial‐derived cytokines. The impact of BaP on Der f 1‐induced airway epithelial cell oxidative stress (ROS) and cytokine release was further analyzed. The role of aryl hydrocarbon receptor (AhR) signaling in BaP‐promoted Der f 1‐induced ROS, cytokine production, and allergic inflammation was also investigated. Results Compared with Der f 1, BaP co‐exposure with Der f 1 led to airway hyper‐responsiveness and increased lung inflammation in mouse model of asthma. Increased expression of TSLP, IL‐33, and IL‐25 was also found in the airways of these mice. Moreover, BaP co‐exposure with Der f 1 activated AhR signaling with increased expression of AhR and CYP1A1 and promoted airway epithelial ROS generation and TSLP and IL‐33, but not IL‐25, expression. Interestingly, AhR antagonist CH223191 or cells with AhR knockdown abrogated the increased expression of ROS, TSLP, and IL‐33. Furthermore, ROS inhibitor N‐acetyl‐L‐cysteine (NAC) also suppressed BaP co‐exposure‐induced expression of epithelial TSLP, IL‐33, and IL‐25. Finally, AhR antagonist CH223191 and NAC inhibited BaP co‐exposure with Der f 1‐induced lung inflammation. Conclusions Our findings suggest that BaP facilitates Der f 1‐induced epithelial cytokine release through the AhR‐ROS axis.
机译：抽象背景与过敏原共存的环境污染物与哮喘的加剧有关。然而，潜在的分子机制仍然难以捉摸。我们试图确定苯佐（A）芘（BAP）与皮肤病组吗？1？过敏原（Der F 1）可以使哮喘诱导的哮喘及其潜在机制有效。方法对哮喘的DER F 1诱导的小鼠模型研究了BAP的影响，包括气道超响应性，过敏性炎症和上皮衍生的细胞因子。进一步分析了BAP对DER F 1诱导的气道上皮细胞氧化应激（ROS）和细胞因子释放的影响。还研究了芳基烃受体（AHR）信号传导在BAP促进的DER F 1诱导的ROS，细胞因子产生和过敏性炎症中的作用。结果与DER F 1相比，BAP与DER F 1的共同暴露导致气道超响应性和哮喘小鼠模型中的肺炎。在这些小鼠的气道中也发现了TSLP，IL-33和IL-25的表达增加。此外，通过增加AHR和CYP1A1的表达和促进气道上皮ROS生成和TSLP和IL-33的促进AHR信号传导的BAP共曝光。有趣的是，AHR拮抗剂CH223191或具有AHR敲低的细胞废除了ROS，TSLP和IL-33的增加。此外，ROS抑制剂N-乙酰基-1-半胱氨酸（NAC）也抑制了上皮TSLP，IL-33和IL-25的鲍巴共曝光诱导的表达。最后，AHR拮抗剂CH223191和NAC抑制BAP与DER F 1诱导的肺炎症的共接暴露。结论我们的研究结果表明，BAP通过AHR-ROS轴促进了诱导的上皮细胞因子释放。

著录项

  • 来源
    《Allergy》 |2019年第9期|共16页
  • 作者

    Wang Eryi; Liu Xiaoyu; Tu Wei; Do Danh C.; Yu Haiqiong; Yang Liteng; Zhou Yufeng; Xu Damo; Huang Shau‐Ku; Yang Pingchang; Ran Pixin; Gao Pei‐Song; Liu Zhigang;

  • 作者单位

    The Affiliated Luohu Hospital of Shenzhen University Shenzhen Luohu Hospital GroupShenzhen China;

    The State Key Laboratory of Respiratory Disease for Allergy Shenzhen University School of;

    The Affiliated Luohu Hospital of Shenzhen University Shenzhen Luohu Hospital GroupShenzhen China;

    Johns Hopkins Asthma and Allergy CenterJohns Hopkins University School of MedicineBaltimore Maryland;

    The Affiliated Luohu Hospital of Shenzhen University Shenzhen Luohu Hospital GroupShenzhen China;

    The Affiliated Luohu Hospital of Shenzhen University Shenzhen Luohu Hospital GroupShenzhen China;

    Key Laboratory of Neonatal Disease Ministry of Health Children's Hospital and Institute of;

    Institute of Infection Immunity and InflammationUniversity of GlasgowGlasgow UK;

    The Affiliated Luohu Hospital of Shenzhen University Shenzhen Luohu Hospital GroupShenzhen China;

    The Affiliated Luohu Hospital of Shenzhen University Shenzhen Luohu Hospital GroupShenzhen China;

    Guangzhou Institute of Respiratory Disease State Key Laboratory of Respiratory Diseases The First;

    Johns Hopkins Asthma and Allergy CenterJohns Hopkins University School of MedicineBaltimore Maryland;

    The Affiliated Luohu Hospital of Shenzhen University Shenzhen Luohu Hospital GroupShenzhen China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    Aryl hydrocarbon receptor; benzo(a)pyrene (BaP); dermatophagoides group 1 allergen (Der f 1); IL‐25; IL‐33; reactive oxygen species; TSLP;

    机译：芳基烃受体;苯并（a）芘（BAP）;皮肤病第1组过敏原（der F 1）;IL-25;IL-33;反应性氧物种;TSLP;

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