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首页> 外文期刊>Allergy >Deserters on the atopic march: Risk factors, immune profile and clinical outcomes of food sensitized–tolerant infants
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Deserters on the atopic march: Risk factors, immune profile and clinical outcomes of food sensitized–tolerant infants

机译：Atopic 3月的逃兵：危险因素，免疫剖面和食物致敏耐受性婴儿的临床结果

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Abstract Background A few studies have investigated the antecedents and outcomes of infants who demonstrate IgE sensitization to foods that they clinically tolerate. Improved understanding of this sensitized‐tolerant phenotype may inform strategies for the prevention of food allergy. Methods In an Australian birth cohort (n?=?1074), assembled using an unselected antenatal sampling frame, participants were categorized as nonsensitized (NS), sensitizedtolerant (ST), or food allergic (FA) based on skin prick testing and food challenge at 12?months of age. Environmental exposures were recorded throughout. Cord blood regulatory T‐cell populations were measured at birth. Subsequent childhood allergic disease was assessed by parent report, clinical examination, and repeat skin prick testing. Results The covariates of interest varied between NS (n?=?698), ST (n?=?27), and FA (n?=?61) groups as follows, suggesting that across these measures, the ST group was more similar to the NS than the FA group: family history of eczema NS 44.6%, ST. 44.6%, FA 65.6%; pet ownership at 12?months: NS 71.5%, ST 81.5%, FA 45.8%; eczema during the first 12?months: NS 19%, ST 32%, FA 64%; and aeroallergen sensitization at 4?years: NS 19.1%, ST 28.6%, FA 44.4%. At birth, a higher proportion of activated regulatory T cells was associated with ST (OR?=?2.89, 95% CI 1.03‐8.16, P ?=?.045). Conclusion Food‐sensitized‐tolerance in infancy appears to be associated with a similar pattern of exposures, immunity, and outcomes to nonsensitized infants. In addition, we found some evidence that an elevated proportion of activated regulatory T cells at birth was specific to the sensitized‐tolerant infants, which may be relevant to suppression of clinical disease.
机译：摘要背景研究了一些研究调查了婴儿的前一种和结果，他们向他们临床耐受的食物表现出敏感性。改善了对这种致敏的表型的理解可以为预防食物过敏的策略提供信息。使用未选择的产前采样帧组装的澳大利亚出生队列（N？= 1074）中的方法，参与者被分类为基于皮肤刺测试和食物挑战的非抗病（NS），敏化致敏（ST）或食物过敏（FA）在12个月的时间。整个环境暴露都记录了。在出生时测量脐带血性T细胞群。通过父母报告，临床检查和重复皮肤刺测试评估随后的儿童过敏性疾病。结果NS（n？=Δ698）之间的感兴趣变化，st（n？=Δ27），以及fa（n？=Δ61）组，如下所述，表明在这些措施中，St组更相似到NS而不是FA组：湿疹NS 44.6％的家族史，ST。 44.6％，FA 65.6％;宠物所有权12？几个月：NS 71.5％，ST 81.5％，FA 45.8％;湿疹在前12个月？几个月：NS 19％，ST 32％，FA 64％;和空气过敏剂致敏4年？年：NS 19.1％，ST 28.6％，FA4.4％。在出生时，较高比例的活化调节性T细胞与ST（或？=？2.89,95％CI 1.03-8.16，P？= 045）​​。结论婴儿期的食物致敏耐受性似乎与类似的曝光，免疫和结果模式相关。此外，我们发现一些证据表明，出生时的活化调节性T细胞的升高比例是敏化耐受性婴儿的升高，这可能与抑制临床疾病相关。

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