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首页> 外文期刊>ACS catalysis >Ion Pair-Directed C-H Activation on Flexible Ammonium Salts: meta-Selective Borylation of Quaternized Phenethylamines and Phenylpropylamines
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Ion Pair-Directed C-H Activation on Flexible Ammonium Salts: meta-Selective Borylation of Quaternized Phenethylamines and Phenylpropylamines

机译：柔性铵盐的离子对导的C-H激活：季铵化苯胺和苯丙胺的Meta选择性促进酚醛化

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摘要

Ion pairing has unexplored potential as a key catalyst-substrate interaction for controlling regioselectivity and site-selectivity in transition metal catalysis, particularly in the area of C-H activation. However, there is a significant perceived challenge that has meant that few have investigated this approach to date-that of the low directionality, which could present an unsurmountable challenge if seeking positional selectivity on flexible substrates. Herein, we demonstrate that even flexible substrates with several freely rotatable bonds undergo ion pair-directed C-H borylation with good to excellent levels of regiocontrol for the arene meta-position. Furthermore, we demonstrate that in specially designed competition substrates, ion pair direction prevails over competing hydrogen bond direction. We anticipate that these findings will inspire the greater incorporation of ion-pairing into site-selective catalytic strategies.
机译：离子配对具有作为用于控制过渡金属催化中的区域选择性和位点选择性的关键催化剂底物相互作用的未探测电位，特别是在C-H激活面积中。 然而，存在显着的感知挑战，这意味着很少有人调查了迄今为止的这种方法 - 如果在柔性基板上寻找位置选择性，这可能会出现不可思议的挑战。 在此，我们证明了甚至具有若干可自由可旋转的粘合的柔性基材经历离子对导的C-H促进型，与芳烃元定位的优异含量的再生水平。 此外，我们证明，在专门设计的竞争基板中，离子对方向在竞争氢键方向上占地。 我们预计这些发现将激发离子配对的更加掺入，进入位点选择性催化策略。

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