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首页> 外文期刊>Acta neurobiologiae experimentalis >Dendrites as separate compartment - local protein synthesis.
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Dendrites as separate compartment - local protein synthesis.

机译：树突作为单独的区室-局部蛋白质合成。

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The article summarizes the most meaningful studies which have provided evidence that protein synthesis in neurons can occur not only in cell perikarya but also locally in dendrites. The presence of the complete machinery required to synthesize cytoplasmic and integral membrane proteins in dendrites, identification of binding proteins known to mediate mRNA trafficking in dendrites and the ability to trigger "on-site" translation make it possible for the synthesis of particular proteins to be regulated by synaptic signals. Until now over 100 different mRNAs coding the proteins involved in neurotransmission and modulation of synaptic activity have been identified in dendrites. Local protein synthesis is postulated to provide the basic mechanism of fast changes in the strength of neuronal connections and to be an important factor in the molecular background of synaptic plasticity, giving rise to enduring changes in synaptic function, which in turn play a role in local homeostatic responses. Local protein synthesis points to some autonomy of dendrites which makes them "the brains of the neurons" (Jim Eberwine; from the interview with J. Eberwine - Barinaga 2000).
机译：这篇文章总结了最有意义的研究，这些研究提供了证据，证明神经元中的蛋白质合成不仅可以在细胞周核组织中发生，而且可以在树突中局部发生。合成树突状细胞质和整合膜蛋白所需的完整机制的存在，鉴定介导树突状细胞中mRNA转运的结合蛋白的鉴定以及触发“现场”翻译的能力，使得特定蛋白质的合成成为可能由突触信号调节。迄今为止，在树突中已经鉴定出超过100种不同的mRNA，它们编码参与神经传递和突触活性调节的蛋白质。推测局部蛋白质合成可提供神经元连接强度快速变化的基本机制，并且是突触可塑性分子背景中的重要因素，从而引起突触功能的持久变化，进而在局部神经元中发挥作用。稳态反应。局部蛋白质合成表明树突具有一定的自主性，使树突成为“神经元的大脑”（吉姆·埃伯维恩;摘自J.埃伯维恩的访谈-Barinaga 2000）。

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