Nickel-Catalyzed C-O Bond-Cleaving Alkylation of Esters: Direct Replacement of the Ester Moiety by Functionalized Alkyl Chains

Liu Xiangqian; Jia Jiaqi; Rueping Magnus

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Nickel-Catalyzed C-O Bond-Cleaving Alkylation of Esters: Direct Replacement of the Ester Moiety by Functionalized Alkyl Chains

机译：镍催化的C-O键合烷基化酯：通过官能化烷基链直接替换酯部分

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摘要

Two efficient protocols for the nickel-catalyzed aryl alkyl cross-coupling reactions using esters as coupling components have been established. The methods enable the selective oxidative addition of nickel to acyl C-O and aryl C-O bonds and allow the aryl alkyl cross-coupling via decarbonylative bond cleavage or through cleavage of a C-O bond with high efficiency and good functional group compatibility. The protocols allow the streamlined, unconventional utilization of widespread ester groups and their precursors, carboxylic acids and phenols, in synthetic organic chemistry.

机译：已经建立了使用酯作为偶联组分的镍催化芳基烷基交联反应的两种有效方案。该方法使得选择性氧化氧化镍与酰基C-O和芳基C-O键合，并允许通过脱羰键切割或通过高效率和良好的官能团相容性切割C-O键的芳基烷基。该方案允许合成有机化学中的流线型，非常规利用广泛的酯基及其前体，羧酸和酚类。

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来源
《ACS catalysis》 |2017年第7期|共6页
作者
Liu Xiangqian; Jia Jiaqi; Rueping Magnus;
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作者单位

Rhein Westfal TH Aachen Inst Organ Chem Landoltweg 1 D-52074 Aachen Germany;

Rhein Westfal TH Aachen Inst Organ Chem Landoltweg 1 D-52074 Aachen Germany;

Rhein Westfal TH Aachen Inst Organ Chem Landoltweg 1 D-52074 Aachen Germany;

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原文格式 PDF
正文语种 eng
中图分类物理化学（理论化学）、化学物理学;
关键词
cross-coupling; C-O activation; alkylation; decarbonylation; nickel catalysis;

机译：交叉偶联;C-O活化;烷基化;脱羰;镍催化;

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1. Nickel-Catalyzed C-O Bond-Cleaving Alkylation of Esters: Direct Replacement of the Ester Moiety by Functionalized Alkyl Chains [J] . Liu Xiangqian, Jia Jiaqi, Rueping Magnus ACS catalysis . 2017,第7期

机译：镍催化的C-O键合烷基化酯：通过官能化烷基链直接替换酯部分
2. Synthesis of poly(2-oxazoline)s with side chain methyl ester functionalities: Detailed understanding of living copolymerization behavior of methyl ester containing monomers with 2-alkyl-2-oxazolines [J] . Bouten P. J. M., Hertsen Dietmar, Vergaelen Maarten, Journal of Polymer Science, Part A. Polymer Chemistry . 2015,第22期

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7. Nickel-Catalyzed CO Bond-Cleaving Alkylation of Esters: Direct Replacement of the Ester Moiety by Functionalized Alkyl Chains [O] . -1

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Nickel-Catalyzed C-O Bond-Cleaving Alkylation of Esters: Direct Replacement of the Ester Moiety by Functionalized Alkyl Chains

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