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首页> 外文期刊>Acta Neurochirurgica >Experimental high-altitude intracerebral hemorrhage in minipigs: Histology, behavior, and intracranial pressure in a double-injection model
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Experimental high-altitude intracerebral hemorrhage in minipigs: Histology, behavior, and intracranial pressure in a double-injection model

机译：小型猪的实验性高海拔脑出血：两次注射模型中的组织学，行为和颅内压

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Background: Specific pathophysiological mechanism in intracerebral hemorrhage (ICH) at high altitude is unclear, and at present, there is no relevant and suitable animal model. Methods: A hypobaric chamber was used to simulate an altitude of 4,000 m. Autologous arterial blood (3 ml) was slowly infused into the right basal ganglia of minipigs by a double-injection method for producing ICH. Results: The intracranial pressure and neurological score of the high-altitude group were significantly higher than those of the low-altitude (plain) group. The brain water contents and pathological lesions of perihematoma tissue were more severe in the high-altitude group. Conclusions: The injury resulting from ICH at high altitude was more severe than that in the plain group. This model was able to produce controllable and reproducible hematomas and visible neurological deficits, which may be useful for future studies of the pathophysiology and functional rehabilitation of high-altitude ICH disease.
机译：背景：目前尚不清楚高海拔地区脑出血（ICH）的具体病理生理机制，目前尚无相关且合适的动物模型。方法：使用低压舱模拟4,000 m的高度。通过两次注射法将自体动脉血（3 ml）缓慢注入微型猪的右基底神经节中，以产生ICH。结果：高海拔组的颅内压和神经系统评分明显高于低海拔（普通）组。高海拔组的脑水含量和血肿周围组织的病理损害更为严重。结论：ICH引起的高海拔地区的伤害比平原地区严重。该模型能够产生可控制和可再现的血肿和可见的神经功能缺损，这可能对将来对高海拔ICH疾病的病理生理学和功能康复的研究有用。

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