Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis

MichaelM. Gaschler; Fanghao Hu; Huizhong Feng; Andreas Linkermann; Wei Min; Brent R. Stockwell

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Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis

机译：亚细胞定位的测定抑制脱裂化的亚细胞定位及其作用机理

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Ferroptosis is a form of nonapoptotic cell death characterized by the unchecked accumulation of lipid peroxides. Ferrostatin-1 and its analogs (ferrostatins) specifically prevent ferroptosis in multiple contexts, but many aspects of their molecular mechanism of action remain poorly described. Here, we employed stimulated Raman scattering (SRS) microscopy coupled with small vibrational tags to image the distribution of ferrostatins in cells and found that they accumulate in lysosomes, mitochondria, and the endoplasmic reticulum. We then evaluated the functional relevance of lysosomes and mitochondria to ferroptosis suppression by ferrostatins and found that neither is required for effective ferroptosis suppression.

机译：恶性凋亡是一种非血小凋亡细胞死亡的形式，其特征在于未经检查的脂质过氧化物积累。 Ferrostatin-1及其类似物（Ferrostatins）特异性地防止多种情况下的硬化，但它们分子量的作用机制的许多方面仍然差。这里，我们采用刺激的拉曼散射（SRS）显微镜与小振动标签偶联，以将细胞中的成铁蛋白分布和发现它们积聚在溶酶体，线粒体和内质网中。然后，我们评估了溶酶体和线粒体对铁渗透肌抑制的功能性相关性，发现既不需要有效的硬化抑制。

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《ACS Chemical Biology》 |2018年第4期|共8页
作者
MichaelM. Gaschler; Fanghao Hu; Huizhong Feng; Andreas Linkermann; Wei Min; Brent R. Stockwell;
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Department of Chemistry Columbia University New York New York 10027 United States;

Department of Chemistry Columbia University New York New York 10027 United States;

Department of Biological Sciences Columbia University New York New York 10027 United States;

Medical Clinic III Division of Nephrology Carl Gustav Carus University Hospital at the Technical University Dresden Dresden 01309 Germany;

Department of Chemistry Columbia University New York New York 10027 United States;

Department of Chemistry Columbia University New York New York 10027 United States;

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正文语种 eng
中图分类生物化学;
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1. Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis [J] . MichaelM. Gaschler, Fanghao Hu, Huizhong Feng, ACS Chemical Biology . 2018,第4期

机译：亚细胞定位的测定抑制脱裂化的亚细胞定位及其作用机理
2. Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms [J] . Wang GL, Jiang J Developmental biology . 2004,第2期

机译：多个Cos2 / Ci相互作用通过微管依赖和独立机制调节Ci亚细胞定位
3. Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms [J] . Gelin Wang, Jin Jiang Developmental biology . 2004,第2期

机译：多个Cos2 / Ci相互作用通过微管依赖和独立机制调节Ci亚细胞定位
4. Feature Extraction Approach Selection of Non-GO Termed Proteins for the Backup Method of Protein Subcellular Localization Prediction [C] . Md. Al Mehedi Hasan, Shamim Ahmad, Boshir Ahmed, 2018 International Conference on Computer, Communication, Chemical, Material and Electronic Engineering . 2018

机译：非GO术语蛋白质的特征提取方法选择，用于蛋白质亚细胞定位预测的备用方法
5. Subcellular Localization and Targeting Mechanisms of Arabidopsis Endomembrane Protein 12 (EMP12). [D] . Gao, Caiji. 2012

机译：拟南芥内膜蛋白12（EMP12）的亚细胞定位和靶向机制。
6. Determination of the subcellular localization and mechanism of action of ferrostatins in suppressing ferroptosis [O] . Michael M. Gaschler, Fanghao Hu, Huizhong Feng, -1

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7. Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms [O] . Wang Gelin, Jiang Jin 2004

机译：多个Cos2 / Ci相互作用通过微管依赖和独立机制调节Ci亚细胞定位
8. Determination of the Cellular and Subcellular Localization of 125I- and Radioactively Labeled Thyroid Hormone in the Thyroid, Pituitary and Hypothalamus for the period October 1, 1972-June 30, 1973 [R] . 1973

机译：1972年10月1日至1973年6月30日期间测定甲状腺，垂体和下丘脑中125I-和放射性标记的甲状腺激素的细胞和亚细胞定位

Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis

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