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首页> 外文期刊>ACS Macro Letters >Compartmentalization and Unidirectional Cross-Domain Molecule Shuttling of Organometallic Single-Chain Nanoparticles
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Compartmentalization and Unidirectional Cross-Domain Molecule Shuttling of Organometallic Single-Chain Nanoparticles

机译：有机金属单链纳米粒子的划分和单向跨域分子血管

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摘要

Compartmentalization and unidirectional cross domain molecule shuttling are omnipresent in proteins, and play key roles in molecular recognition, enzymatic reaction, and other living functions. Nanomachinery design emulating these biological functions is being considered as one of the most ambitious and challenging tasks in modern chemistry and nanoscience. Here, we present a biomimetic nanomachinery design using single-chain technology. Stepwise complex of the outer blocks of water-soluble linear ABC triblock terpolymer to copper ions yields dumbbell-shaped single-chain nano particle. A novel nanomachine capable of compartmentalization and unidirectional cross-domain molecule shuttling has been achieved upon ascorbic acid reduction, leading to synergistically donating/accepting copper centers between discrete double heads, overall dumbbell-to-tadpole configurational transition, and intake of oxidized ascorbic acid into reconstructed head. Subsequent air oxidation results in the inverse molecule shuttling and configurational transition processes. This is the first demonstration of biomimetic nanomachinery design that is capable of compartmentalization and unidirectional cross-domain molecule shuttling, exemplified simply using a new single-chain technology.
机译：分区化和单向横域分子分子出血是蛋白质中的无所话，并在分子识别，酶促反应和其他生活功能中起关键作用。纳米机械设计模拟这些生物学功能被认为是现代化学和纳米科学中最雄心勃勃和挑战性的任务之一。在这里，我们使用单链技术提出了一种仿生纳米机械设计。水溶性线性ABC三嵌段三元共聚物到铜离子的外块的逐步复合物产生哑铃形单链纳米颗粒。在抗坏血酸还原过程中已经实现了一种能够进行分区和单向横域分子分子出血的新型纳米机，导致在离散的双头，总体哑铃 - 蝌蚪配置转变和摄入氧化抗坏血酸中之间的协同捐赠/接受铜中心重建头部。随后的空气氧化导致反相分子穿梭和配置过渡过程。这是仿生纳米机械设计的第一次演示，其能够进行隔间化和单向跨域分子出血，简单地使用新的单链技术。

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  • 来源
    《ACS Macro Letters》 |2018年第5期|共7页
  • 作者

    Cui Zhigang; Huang Leilei; Ding Yi; Zhu Xuechao; Lu Xinhua; Cai Yuanli;

  • 作者单位

    Soochow Univ Coll Chem Chem Engn &

    Mat Sci State Local Joint Engn Lab Novel Funct Polymer Ma Suzhou 215123 Peoples R China;

    Soochow Univ Coll Chem Chem Engn &

    Mat Sci State Local Joint Engn Lab Novel Funct Polymer Ma Suzhou 215123 Peoples R China;

    Soochow Univ Coll Chem Chem Engn &

    Mat Sci State Local Joint Engn Lab Novel Funct Polymer Ma Suzhou 215123 Peoples R China;

    Soochow Univ Coll Chem Chem Engn &

    Mat Sci State Local Joint Engn Lab Novel Funct Polymer Ma Suzhou 215123 Peoples R China;

    Soochow Univ Coll Chem Chem Engn &

    Mat Sci State Local Joint Engn Lab Novel Funct Polymer Ma Suzhou 215123 Peoples R China;

    Soochow Univ Coll Chem Chem Engn &

    Mat Sci State Local Joint Engn Lab Novel Funct Polymer Ma Suzhou 215123 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 有机化学;
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