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首页> 外文期刊>ACS Macro Letters >pH-Responsive Micellar Nanoassemblies from Water-Soluble Telechelic Homopolymers Endcoding Acid-Labile Middle-Chain Groups in Their Hydrophobic Sequence-Defined Initiator Residue
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pH-Responsive Micellar Nanoassemblies from Water-Soluble Telechelic Homopolymers Endcoding Acid-Labile Middle-Chain Groups in Their Hydrophobic Sequence-Defined Initiator Residue

机译：PH-响应胶束纳米结合型来自水溶性遥均聚物的疏水性依赖于酸序列定义引发剂残基的酸不稳定中间链组

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摘要

A middle-chain cleavable telechelic poly(oligoethylene glycol) methyl ether acrylate) (MCCT-POEGA-Br) was synthesized by single-electron transfer living radical polymerization (SET-LRP) initiated from an acetal-containing hydrophobic sequence-defined difunctional initiator. In aqueous medium, above a certain concentration, this hydrophilic homopolymer self-assembled into nanogel-like large micelles that exhibit an encapsulating capacity for both hydrophobic and hydrophilic cargo. The sequence-defined cleavage pattern encoded in the initiator residue allowed precise middle-chain cleavage, leading to quantitative disassembly of the corresponding nanoobjects. Dye release studies performed in an acidic environment demonstrated the potential of this new design concept in the preparation of pH-responsive nanocarriers. In addition, fluorescently tagged nanoassemblies could also be obtained via the thio-bromo "click" modification of MCCT-POEGA-Br prior to self-assembly. This strategy may provide facile access to a diversity of multistimuli-responsive nanocarriers based on commercially available hydrophilic monomers and sequence-defined difunctional initiators synthesized by this simple design strategy.
机译：通过从含抗缩醛的疏水性序列定义的双官能引发剂引发的单电子转移活性自由基聚合（SET-LRP）合成中间链可切割的左右甲基丙烯酸甲基醚丙烯酸酯）（MCCT-POEGA-BR）。在水性介质中，高于一定浓度，这种亲水性均聚物将自组装成纳米凝胶状大胶束，其表现出疏水性和亲水性货物的包封能力。在引发剂残基中编码的序列定义的裂解图案允许精确的中链切割，导致相应的纳米料的定量拆卸。在酸性环境中进行的染料释放研究证明了这种新设计概念在制备pH响应纳米载体中的潜力。此外，还可以通过在自组装之前通过硫代 - Bromo“点击”修改来获得荧光标记的纳米组织。该策略可以基于可商购的亲水性单体和通过这种简单的设计策略合成的序列定义的双官能引发剂来提供对多体响应纳米载体的多样性的容易获得。

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  • 来源
    《ACS Macro Letters》 |2019年第9期|共9页
  • 作者

    Moreno Adrian; Ronda Juan C.; Cadiz Virginia; Galia Marina; Lligadas Gerard; Percec Virgil;

  • 作者单位

    Univ Rovira &

    Virgili Dept Analyt Chem &

    Organ Chem Lab Sustainable Polymers E-43007 Tarragona Spain;

    Univ Rovira &

    Virgili Dept Analyt Chem &

    Organ Chem Lab Sustainable Polymers E-43007 Tarragona Spain;

    Univ Rovira &

    Virgili Dept Analyt Chem &

    Organ Chem Lab Sustainable Polymers E-43007 Tarragona Spain;

    Univ Rovira &

    Virgili Dept Analyt Chem &

    Organ Chem Lab Sustainable Polymers E-43007 Tarragona Spain;

    Univ Rovira &

    Virgili Dept Analyt Chem &

    Organ Chem Lab Sustainable Polymers E-43007 Tarragona Spain;

    Univ Penn Dept Chem Roy &

    Diana Vagelos Labs Philadelphia PA 19104 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 有机化学;
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