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首页> 外文期刊>ACS Macro Letters >Double-Cross-Linked Hydrogel Strengthened by UV Irradiation from a Hyperbranched PEG-Based Trifunctional Polymer
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Double-Cross-Linked Hydrogel Strengthened by UV Irradiation from a Hyperbranched PEG-Based Trifunctional Polymer

机译：通过紫外线辐照加强双交联水凝胶，来自基于超支的PEG的三官能聚合物

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摘要

Conventional wound healing materials suffer from low efficiency, poor mechanical strength, and nontunable properties. Responsive hydrogels are appealing candidates for tissue engineering. Herein, we developed a double-cross-linked hydrogel system composed of hyperbranched PEG-based polymer, comprising pre-cross-linked acetal structure and numerous terminal acrylate groups, which can form hydrogels in situ and can be further strengthened by UV irradiation. The hyperbranched glycidyl methacrylate-co-poly(ethylene glycol) diacrylate polymers (HB-GMA-PEGs) were first synthesized via in situ deactivation enhanced atom transfer radical polymerization (DE-ATRP). A series of pre-cross-linked materials were achieved after postfunctionalization. The material can absorb a high amount of water to form hydrogels, and the gel stiffness was evaluated in detail before and after UV irradiation. The in vitro cytotoxicity experiments were conducted with the resulting materials and have demonstrated their good biocompatibility. The results indicate that this type of hydrogel with high water uptake capacity has appealing potential as a responsive biomaterial for wound closure.
机译：常规的伤口愈合材料患有低效率，机械强度差和无难度性质。敏感水凝胶是组织工程的吸引人候选者。在此，我们开发了由超支化的PEG基聚合物组成的双交联水凝胶系统，其包含预交联的缩醛结构和许多末端丙烯酸酯基团，其可以原位形成水凝胶，并且可以通过UV辐射进一步加强。首先通过原位去激活增强的原子转移自由基聚合（DE-ATRP）首先合成超胆糖化丙烯酸甲酯 - 共聚（乙二醇）二丙烯酸酯聚合物（HB-GMA-PEG）。在后官能化之后实现了一系列的交联预连接材料。该材料可以吸收大量水以形成水凝胶，并在UV辐射之前和之后详细评估凝胶刚度。用所得材料进行体外细胞毒性实验，并证明了它们的良好生物相容性。结果表明，这种具有高水吸收能力的水凝胶具有吸引潜力作为伤口闭合的响应性生物材料。

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  • 来源
    《ACS Macro Letters》 |2018年第5期|共9页
  • 作者

    Xu Qian; Sigen A.; McMichael Peter; Creagh-Flynn Jack; Zhou Dezhong; Gao Yongsheng; Li Xiaolin; Wang Xi; Wang Wenxin;

  • 作者单位

    Univ Coll Dublin Sch Med Charles Inst Dermatol Dublin 4 Ireland;

    Univ Coll Dublin Sch Med Charles Inst Dermatol Dublin 4 Ireland;

    ENSIACET INP Toulouse France;

    Univ Coll Dublin Sch Med Charles Inst Dermatol Dublin 4 Ireland;

    Univ Coll Dublin Sch Med Charles Inst Dermatol Dublin 4 Ireland;

    Univ Coll Dublin Sch Med Charles Inst Dermatol Dublin 4 Ireland;

    Univ Coll Dublin Sch Med Charles Inst Dermatol Dublin 4 Ireland;

    Univ Coll Dublin Sch Med Charles Inst Dermatol Dublin 4 Ireland;

    Univ Coll Dublin Sch Med Charles Inst Dermatol Dublin 4 Ireland;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 有机化学;
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