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Inhibition of Ice Recrystallization by Nylon-3 Polymers

机译：尼龙-3聚合物抑制冰重结晶

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src="http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/amlccd/2017/amlccd.2017.6.issue-7/acsmacrolett.7b00396/20170712/images/medium/mz-2017-00396v_0006.gif">Nontoxic cryoprotectants are needed for storage of tissues and food preservation. Frozen tissue is particularly susceptible to damage caused by formation of large ice crystals during the thawing process. The current practice of using 5 wt % DMSO for cryopreservation does not produce 100% cell viability post-thaw, at least in part because of DMSO toxicity that is manifested during the freezing and thawing stages of the process. Recently, poly(vinyl alcohol) (PVA) has shown promise in inhibiting ice recrystallization, an activity that is critical for cryoprotection. Inspired by this discovery, we have evaluated nylon-3 polymers for ice recrystallization inhibition activity and for toxicity toward mammalian cells. A survey of homo- and heteropolymers, with side chains bearing variable functionality, has identified new nylon-3 materials that display excellent ice recrystallization inhibition activity and low toxicity.
机译：src =“http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/amlccd/2017/amlccd.2017.6.issue-7/acsmacrolett.7b00396/20170712/image/medium/mz -2017-00396V_0006.GIF“>储存组织和食物保存需要无毒冷冻保护剂。冷冻组织特别容易受到在解冻过程中形成大冰晶引起的损伤。使用5wt％DMSO对冷冻保存的目前的实践不会产生100％的细胞活力后解冻后，至少部分是由于在该方法的冷冻和解冻阶段中表现出的DMSO毒性。最近，聚（乙烯醇）（PVA）在抑制冰重结晶时显示了希望，这是一种对冷冻保护至关重要的活动。灵感来自这一发现，我们已经评估了尼龙-3用于冰重结晶抑制活性的聚合物，并对对哺乳动物细胞的毒性进行毒性。具有侧链轴承变量功能的同源和杂多聚合物的调查已经确定了新的尼龙-3材料，其显示出优异的再结晶抑制活性和低毒性。

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  • 来源
    《ACS Macro Letters》 |2017年第7期|共5页
  • 作者

    Melissa J. MacDonald; Natasha R. Cornejo; Samuel H. Gellman;

  • 作者单位

    Department of Chemistry University of Wisconsin—Madison Madison Wisconsin 53706 United States;

    Department of Chemistry University of Wisconsin—Madison Madison Wisconsin 53706 United States;

    Department of Chemistry University of Wisconsin—Madison Madison Wisconsin 53706 United States;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 有机化学;
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