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首页> 外文期刊>ACS Macro Letters >Design and Synthesis of New Sulfur-Containing Hyperbranched Polymer and Theranostic Nanomaterials for Bimodal Imaging and Treatment of Cancer
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Design and Synthesis of New Sulfur-Containing Hyperbranched Polymer and Theranostic Nanomaterials for Bimodal Imaging and Treatment of Cancer

机译：含硫的超支化聚合物和治疗型癌症纳米材料的设计与合成癌症

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src="http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/amlccd/2017/amlccd.2017.6.issue-3/acsmacrolett.7b00008/20170315/images/medium/mz-2017-00008z_0007.gif">In this study, we have synthesized a new hyperbranched polyester polymer containing sulfur-pendants (HBPE-S) in the branching points. This HBPE-S polymer is composed of spherical shaped, aliphatic three-dimensional architecture with carboxylic acid groups on the surface. The presence of sulfur pendants in the polymeric cavities demonstrated an important role in the effective encapsulation of Bi-DOTA complexes ([Bi] = 5.21 μM), when compared to the previously reported polymer without sulfur pendants (HBPE, [Bi] = 1.07 × 10–3 μM). Higher X-ray blocking capability and excellent X-ray contrast images were obtained from Bi-DOTA encapsulating HBPE-S polymeric nanoparticles when compared with that of HBPE nanoparticles. In addition, the HBPE-S polymer’s spherical structure with amphiphilic cavities allow for the successful encapsulation of antitumor drugs and optical dyes, indicating suitable for delivery of wide-range of theranostic agents for cancer diagnosis and treatment. Therapeutic drug taxol encapsulating, folic acid decorated HBPE-S-Fol nanoparticles showed more than 80% of lung carcinoma cell death within 24 h of incubation. Cell viability and microscopic experiments also confirmed for the targeted delivery, thereby minimizing toxicity to healthy tissues. Taken together, new HBPE-S polymer and multimodal theranostic nanoplatforms were synthesized with enhanced X-ray blocking capability for the effective cancer targeting and treatment monitoring.
机译：src =“http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/amlccd/2017/amlccd.2017.6.issue-3/acsmacrolett.7b0000008/20170315/image/medium/mz -2017-00008Z_0007.gif“>在本研究中，我们在分支点中合成了含有硫坠子（HBPE-S）的新的超支化聚酯聚合物。该HBPE-S聚合物由球形构成，表面上具有羧酸基团的脂族三维架构。聚合物腔中的硫侧链的存在在与先前报道的聚合物相比，在双点络合物的有效包封（[Bi] =5.21μm）中的有效包封中的重要作用在没有硫坠子（HBPE，[Bi] = 1.07× 10 -3 μm）。与HBPE纳米颗粒相比，从双点封装HBPE-S聚合物纳米粒子获得较高的X射线阻断能力和优异的X射线对比度。此外，具有两亲腔的HBPE-S聚合物的球形结构允许成功封装抗肿瘤药物和光学染料，表明适于递送广泛的治疗剂用于癌症诊断和治疗。治疗药物紫杉醇包封，叶酸装饰HBPE-S-FOL纳米粒子在孵育24小时内显示出超过80％的肺癌细胞死亡。细胞活力和微观实验也证实了靶向递送，从而最小化对健康组织的毒性。结合在一起，用增强的X射线阻断能力合成了新的HBPE-S聚合物和多式联运纳米纳薄晶形，用于有效的癌症靶向和治疗监测。

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  • 来源
    《ACS Macro Letters》 |2017年第3期|共6页
  • 作者

    Blaze Heckert; Tuhina Banerjee; Shoukath Sulthana; Shuguftha Naz; Riyadh Alnasser; Deaven Thompson; Guillaume Normand; Jan Grimm; J. Manuel Perez; Santimukul Santra;

  • 作者单位

    Department of Chemistry Pittsburg State University 1701 South Broadway Street Pittsburg Kansas 66762 United States;

    Department of Chemistry Pittsburg State University 1701 South Broadway Street Pittsburg Kansas 66762 United States;

    Department of Chemistry Pittsburg State University 1701 South Broadway Street Pittsburg Kansas 66762 United States;

    Department of Chemistry Pittsburg State University 1701 South Broadway Street Pittsburg Kansas 66762 United States;

    Department of Chemistry Pittsburg State University 1701 South Broadway Street Pittsburg Kansas 66762 United States;

    Department of Chemistry Pittsburg State University 1701 South Broadway Street Pittsburg Kansas 66762 United States;

    Department of Radiology and Molecular Pharmacology Program Memorial Sloan Kettering Cancer Center 1275 York Avenue New York New York 10065 United States;

    Department of Radiology and Molecular Pharmacology Program Memorial Sloan Kettering Cancer Center 1275 York Avenue New York New York 10065 United States;

    Nanoscience Technology Center University of Central Florida Orlando Florida 32826 United States;

    Department of Chemistry Pittsburg State University 1701 South Broadway Street Pittsburg Kansas 66762 United States;

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  • 正文语种 eng
  • 中图分类 有机化学;
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