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首页> 外文期刊>ACS Macro Letters >Responsive Nanogel Probe for Ratiometric Fluorescent Sensing of pH and Strain in Hydrogels
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Responsive Nanogel Probe for Ratiometric Fluorescent Sensing of pH and Strain in Hydrogels

机译：水凝胶中pH与菌株的响应性纳米凝胶探针

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src="http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/amlccd/2017/amlccd.2017.6.issue-11/acsmacrolett.7b00709/20171115/images/medium/mz-2017-007099_0006.gif">In this study a new pH-responsive nanogel probe containing a complementary nonradiative resonance energy transfer (NRET) fluorophore pair is investigated and its ability to act as a versatile probe of network-related changes in three hydrogels demonstrated. Fluorescent sensing using NRET is a powerful method for studying relationships between Angstrom length-scale structure and macroscopic properties of soft matter. Unfortunately, inclusion of NRET fluorophores into such materials requires material-specific chemistry. Here, low concentrations of preformed nanogel probes were included into hydrogel hosts. Ratiometric photoluminescence (PL) data for the gels labeled with the nanogel probes enabled pH-triggered swelling and deswelling to be studied as well as Ca2+-triggered collapse and solute release. PL measurements during compression of a nanogel probe-labeled nanocomposite gel demonstrated mechanochromic behavior and strain sensing. The new nanogel probes have excellent potential for investigating the internal structures of gels and provide a versatile ratiometric fluorescent platform for studying pH and strain.
机译：src =“http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/amlccd/2017/amlccd.2017.6.issue-11/acsmacrolett.7b00709/20171115/images/medium/mz -2017-007099_0006.gif“>在本研究中，研究了含有互补的非抗体共振能量转移（NRET）荧光团对的新的pH响应纳米凝胶探针，并表现为三种水凝胶中的网络相关变化的多功能探针的能力。使用NRET的荧光感测是研究埃斯特罗姆长度结构与柔软物质宏观性质之间关系的强大方法。不幸的是，将NRET荧光团包含到这些材料中需要具有物质特异性化学。这里，将低浓度的预先形成的纳米凝胶探针包含在水凝胶宿主中。用纳米凝胶探针标记的凝胶的比率光致发光（PL）数据使能PH-触发的溶胀和抛弃液以及Ca 2 + - 触发和溶质释放。在压缩纳米凝胶探针标记的纳米复合凝胶期间的PL测量证明了机械密度行为和应变感测。新的纳米凝胶探针具有优异的研究凝胶内部结构的潜力，并为研究pH和菌株提供多功能的比例荧光平台。

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  • 来源
    《ACS Macro Letters》 |2017年第11期|共6页
  • 作者

    Mingning Zhu; Dongdong Lu; Shanglin Wu; Qing Lian; Wenkai Wang; Amir H. Milani; Zhengxing Cui; Nam T. Nguyen; Mu Chen; L. Andrew Lyon; Daman J. Adlam; Anthony J. Freemont; Judith A. Hoyland; Brian R. Saunders;

  • 作者单位

    School of Materials University of Manchester MSS Tower Manchester M13 9PL U.K.;

    School of Materials University of Manchester MSS Tower Manchester M13 9PL U.K.;

    School of Materials University of Manchester MSS Tower Manchester M13 9PL U.K.;

    School of Materials University of Manchester MSS Tower Manchester M13 9PL U.K.;

    School of Materials University of Manchester MSS Tower Manchester M13 9PL U.K.;

    School of Materials University of Manchester MSS Tower Manchester M13 9PL U.K.;

    School of Materials University of Manchester MSS Tower Manchester M13 9PL U.K.;

    School of Materials University of Manchester MSS Tower Manchester M13 9PL U.K.;

    School of Materials University of Manchester MSS Tower Manchester M13 9PL U.K.;

    Schmid College of Science and Technology Chapman University Orange California 92866 United States;

    Division of Cell Matrix Biology and Regenerative Medicine Faculty of Biology Medicine and Health University of Manchester Oxford Road Manchester M13 9PT U.K.;

    Division of Cell Matrix Biology and Regenerative Medicine Faculty of Biology Medicine and Health University of Manchester Oxford Road Manchester M13 9PT U.K.;

    Division of Cell Matrix Biology and Regenerative Medicine Faculty of Biology Medicine and Health University of Manchester Oxford Road Manchester M13 9PT U.K.;

    School of Materials University of Manchester MSS Tower Manchester M13 9PL U.K.;

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  • 正文语种 eng
  • 中图分类 有机化学;
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