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首页> 外文期刊>ACS Macro Letters >Polymers for Fluorescence Imaging of Formaldehyde in Living Systems via the Hantzsch Reaction
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Polymers for Fluorescence Imaging of Formaldehyde in Living Systems via the Hantzsch Reaction

机译：通过Hantzsch反应的生活系统中甲醛荧光成像的聚合物

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摘要

Formaldehyde (FA) has been detected via the Hantzsch reaction for many decades. However, the Hantzsch reaction has been rarely used to detect FA in biological systems due to the disadvantages of small-molecule probes (including toxicity and poor water solubility). In this study, polymeric fluorescent probes were developed to resolve these issues associated with small molecules, and FA in living systems was successfully detected via the Hantzsch reaction. These water-soluble polymers were easily scaled-up (similar to 25 g) by radical polymerization using commercial monomers. These polymers exhibited similar, albeit better, sensitivity to FA compared to water-soluble small molecules, primarily indicative of the advantages of polymers for the detection of FA via the Hantzsch reaction. The polymer structures were highly biocompatible with the probes; thus, these polymers can effectively detect endogenous FA in cells or zebrafish in a safe manner. This result confirmed the superiority of polymers in safety as biocompatible materials. This study highlights a straightforward method for exploring probes for the detection of FA in living systems. It offers functional polymers for bioimaging and extends the application scope of the Hantzsch reaction, reflecting the utility of a broad study of organic reactions in interdisciplinary fields as well as possible key implications in organic chemistry, analytical chemistry, and polymer chemistry.
机译：已经通过Hantzsch反应检测到甲醛（FA）数十年来检测。然而，由于小分子探针（包括毒性和不良水溶性）的缺点，汉坦斯CH反应很少用于检测生物系统中的FA。在该研究中，开发了聚合物荧光探针以解决与小分子相关的这些问题，并且通过汉坦斯CH反应成功地检测到生物系统中的FA。使用商业单体，这些水溶性聚合物容易通过自由基聚合缩放（类似于25g）。与水溶性小分子相比，这些聚合物表现出类似的，虽然更好，对Fa的敏感性，主要指示聚合物通过汉坦斯CH反应检测FA的优点。聚合物结构与探针高度相容;因此，这些聚合物可以在安全的方式有效地检测细胞或斑马鱼中的内源性Fa。该结果证实了具有生物相容性的安全性的聚合物的优越性。本研究突出了一种探索在生活系统中检测到FA的探针的直接方法。它为生物分析提供了功能性聚合物，并延长了汉斯茨契反应的应用范围，反映了广泛研究跨学科领域的有机反应的效用以及有机化学，分析化学和聚合物化学中可能的关键意义。

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  • 来源
    《ACS Macro Letters》 |2018年第11期|共13页
  • 作者

    Liu Guoqiang; Shegiwal Ataulla; Zeng Yuan; Wei Yen; Boyer Cyrille; Haddleton David; Tao Lei;

  • 作者单位

    Tsinghua Univ Dept Chem Minist Educ Key Lab Bioorgan Phosphorus Chem &

    Chem Biol Beijing 100084 Peoples R China;

    Tsinghua Univ Dept Chem Minist Educ Key Lab Bioorgan Phosphorus Chem &

    Chem Biol Beijing 100084 Peoples R China;

    Tsinghua Univ Dept Chem Minist Educ Key Lab Bioorgan Phosphorus Chem &

    Chem Biol Beijing 100084 Peoples R China;

    Tsinghua Univ Dept Chem Minist Educ Key Lab Bioorgan Phosphorus Chem &

    Chem Biol Beijing 100084 Peoples R China;

    UNSW Australia Sch Chem Engn CAMD Sydney NSW 2052 Australia;

    Univ Warwick Dept Chem Coventry CV4 7AL W Midlands England;

    Tsinghua Univ Dept Chem Minist Educ Key Lab Bioorgan Phosphorus Chem &

    Chem Biol Beijing 100084 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 有机化学;
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