B-12-Dependent Protein Oligomerization Facilitates Layer-by-Layer Growth of Photo/Thermal Responsive Nanofilms

Wei Jingling; Wu Wen-Hao; Wang Ri; Yang Zhongguang; Sun Fei; Zhang Wen-Bin

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B-12-Dependent Protein Oligomerization Facilitates Layer-by-Layer Growth of Photo/Thermal Responsive Nanofilms

机译：B-12依赖性蛋白质低聚促进照片/热响应纳米螺纹的层次增长

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摘要

We report the robust growth of an entirely protein-based, photo- and thermoresponsive Layer-by-Layer nanofilm using genetically encoded SpyTag/SpyCatcher chemistry. The process was facilitated by AdoB(12)-induced tetramerization of photoreceptor proteins. Protein cargos can be released from the film in a light-dependent manner, showing its potential for therapeutic protein delivery.

机译：我们通过遗传编码的Spytag / Spycatcher化学报告了完全基于蛋白质，光 - 和热典型的逐层纳米膜的生长。通过Adob（12）促进该方法 - 诱导光感受器蛋白的四聚化。蛋白质尸体可以以光依赖性的方式从膜中释放，显示其对治疗蛋白质递送的可能性。

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《ACS Macro Letters》 |2018年第5期|共9页
作者
Wei Jingling; Wu Wen-Hao; Wang Ri; Yang Zhongguang; Sun Fei; Zhang Wen-Bin;
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作者单位

Peking Univ Key Lab Polymer Chem &

Phys Minist Educ Coll Chem &

Mol Engn Ctr Soft Matter Sci &

Engn Beijing 100871 Peoples R China;

Peking Univ Key Lab Polymer Chem &

Phys Minist Educ Coll Chem &

Mol Engn Ctr Soft Matter Sci &

Engn Beijing 100871 Peoples R China;

Hong Kong Univ Sci &

Technol Dept Chem &

Biol Engn Kowloon Hong Kong Peoples R China;

Hong Kong Univ Sci &

Technol Dept Chem &

Biol Engn Kowloon Hong Kong Peoples R China;

Hong Kong Univ Sci &

Technol Dept Chem &

Biol Engn Kowloon Hong Kong Peoples R China;

Peking Univ Key Lab Polymer Chem &

Phys Minist Educ Coll Chem &

Mol Engn Ctr Soft Matter Sci &

Engn Beijing 100871 Peoples R China;

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正文语种 eng
中图分类有机化学;
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1. B-12-Dependent Protein Oligomerization Facilitates Layer-by-Layer Growth of Photo/Thermal Responsive Nanofilms [J] . Wei Jingling, Wu Wen-Hao, Wang Ri, ACS Macro Letters . 2018,第5期

机译：B-12依赖性蛋白质低聚促进照片/热响应纳米螺纹的层次增长
2. Designing cancer nanodrugs that are highly loaded, pH-responsive,photothermal, and possess a favored morphology: A hierarchical assembly of DOX and layer-by-layer modified rGO [J] . Xiangming Li, Yihe Zhang, Zequn Ma, 中国化学快报（英文版） . 2019,第002期

机译：设计高载量，pH响应，光热且具有良好形态的癌症纳米药物：DOX和逐层修饰的rGO的分层组装
3. The photochemical mechanism of a B-12-dependent photoreceptor protein [J] . Kutta Roger J., Hardman Samantha J. O., Johannissen Linus O., Nature Communications . 2015,第Auga期

机译：B-12依赖性感光蛋白的光化学机理
4. Encapsulation of Stimuli-Responsive Fusion Proteins in Silica: Thermally Responsive Metal Ion-Sensitive Hybrid Membranes [C] . Linying Li, Owen Im, Ashutosh Chilkoti, Materials Research Society Meeting . 2013

机译：二氧化硅中刺激响应融合蛋白的封装：热响应金属离子敏感杂种膜
5. Photo-switching of protein activities by conjugation of photo-responsive polymers to proteins. [D] . Shimoboji, Tsuyoshi. 2001

机译：通过将光响应性聚合物与蛋白质缀合来进行蛋白质活性的光转换。
6. Indocyanine green and poly I:C containing thermo-responsive liposomes used in immune-photothermal therapy prevent cancer growth and metastasis [O] . Li Xu, Wei Zhang, Hae-Bin Park, 2019

机译：用于免疫光热疗法的吲哚菁绿和含I：C的聚I：C热响应脂质体可预防癌症的生长和转移
7. pH Responsive Decomposable Layer-by-Layer Nanofilms and Capsules on the Basis of Tannic Acid [O] . -1

机译：在单宁酸的基础上pH响应可分解的分解层纳米膜和胶囊

B-12-Dependent Protein Oligomerization Facilitates Layer-by-Layer Growth of Photo/Thermal Responsive Nanofilms

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