...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta neurologica Scandinavica. >Cognitive impairment in early-stage non-demented Parkinson's disease patients
【24h】

Cognitive impairment in early-stage non-demented Parkinson's disease patients

机译：早期非痴呆型帕金森氏病患者的认知障碍

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives: In Parkinson's disease (PD), Parkinson's disease dementia (PDD) and Parkinson's disease-mild cognitive impairment (PD-MCI) are common. PD-MCI is a risk factor for developing PDD. Knowledge of cognition in early-stages PD is essential in understanding and predicting the dementia process. Materials and Methods: We describe the cognitive profile in early-stage PD patients with no prior clinical suspicion of cognitive impairment, depression or psychiatric disturbances, and investigate possible features distinguishing patients with cognitive deficits, defining a PD-MCI risk-profile. Single Photon Emission Computerized Tomography (SPECT) DaT-scan and neurological examination confirmed the diagnosis. Mini-mental state examination-, Addenbrooke's Cognitive Examination, Unified Parkinson's Disease Rating Scale scoring, Hoehn &Yahr/Activity of Daily Living staging and a neuropsychological test battery were applied. Mild cognitive impairment patients were identified according to modified criteria by Troster necessarily omitting subjective cognitive complaints. 80 patients, mean age 61.0 years (SD 6.6), mean duration of disease 3.4 years (SD 1.2) were included. 76 patients were neuropsychologically tested. Results: 26 (34%) patients fulfilled modified PD-MCI criteria, 18 (69%) of these showed episodic memory deficits, 14 (54%) executive dysfunction, 13 (50%) language/praxis deficits, 12 (46%) visuospatial/constructional deficits and 9 (35%) attention/working memory deficits. Cognitive impairment was associated with higher Unified Parkinson's Disease Rating scale (UPDRS)-, bradykinesia- and rigidity scores and more symmetric distribution of symptoms, but not tremor scores. Patients with cognitive impairment were less educated. Other demographic and clinical variables were comparable. Conclusions: 34% of early-stage PD patients without prior clinical suspicion of cognitive impairment exhibit cognitive impairment, which is associated to disease severity, especially bradykinesia, rigidity, axial symptoms and less asymmetry of motor symptoms, even at early disease stages and when cognitive symptoms are mild.
机译：目的：在帕金森氏病（PD）中，帕金森氏病痴呆症（PDD）和帕金森氏病轻度认知障碍（PD-MCI）很常见。 PD-MCI是发展PDD的危险因素。早期PD的认知知识对于理解和预测痴呆过程至关重要。材料和方法：我们描述了没有早期临床怀疑有认知障碍，抑郁或精神障碍的PD患者的认知特征，并研究了区分具有认知缺陷的患者的可能特征，定义了PD-MCI风险特征。单光子发射计算机断层扫描（SPECT）DaT扫描和神经系统检查证实了诊断。进行了迷你心理状态检查，阿登布鲁克认知检查，帕金森病统一病情量表评分，Hoehn＆Yahr /日常生活活动分期和神经心理学测试电池。 Troster根据修改后的标准确定了轻度认知障碍患者，但必须省去主观认知障碍。包括80名患者，平均年龄61.0岁（SD 6.6），平均病程3.4年（SD 1.2）。对76例患者进行了神经心理学测试。结果：26（34％）位患者符合改良的PD-MCI标准，其中18位（69％）表现为发作性记忆缺陷，14位（54％）执行功能障碍，13位（50％）语言/实践缺陷，12位（46％）视觉空间/结构缺陷和9（35％）注意/工作记忆缺陷。认知障碍与较高的帕金森病综合评分量表（UPDRS），运动迟缓和僵化评分以及症状的更对称分布相关，而与震颤评分无关。认知障碍患者的教育程度较低。其他人口统计学和临床​​变量具有可比性。结论：34％的没有早期临床认知障碍的PD患者表现出认知障碍，这与疾病的严重程度有关，特别是运动迟缓，僵硬，轴向症状以及运动症状的不对称性降低，即使在疾病早期和认知时症状轻微。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号