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首页> 外文期刊>Acta neurologica Scandinavica. >A2A adenosine receptors and Parkinson's disease severity
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A2A adenosine receptors and Parkinson's disease severity

机译：A2A腺苷受体与帕金森氏病的严重程度

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Objectives: In the last decade, increasing evidence suggests a key role of adenosine in Parkinson's disease (PD) and A2A adenosine receptors (A2AARs) as an important pharmacological target in PD. An overexpression of A2AARs has been found in putamen and in peripheral blood cells of PD patients. The primary aim of this study was to verify whether the alterations in A2AARs in lymphocytes of PD subjects correlate with disease severity. Material and methods: A consecutive sample of PD patients was enrolled. A clinical examination and a face-to-face interview were carried out. A2AARs were investigated to verify the affinity and receptor density in lymphocyte membranes. The data were compared with those found in healthy controls. Moreover, the correlation between A2AAR density and affinity and clinical variables was evaluated in PD patients. Results: In human lymphocyte membranes from PD patients, an increase in A2AAR density and a decrease in A2AAR affinity were found if compared with healthy subjects. A statistically significant correlation between the A2AAR density or affinity and specific clinical parameters as motor and cognitive impairment was detected. Patients with higher A2AAR density and lower affinity were more likely to exhibit motor complications. Conclusions: Parkinson's disease patients show an A2AAR upregulation in lymphocyte membranes if compared with healthy subjects. The correlation found between A2AAR density or affinity and clinical parameters highlights the central role of A2AAR modulation in the pharmacological treatment for PD and could suggest the putative role of A2AAR as a candidate biomarker of PD severity.
机译：目的：在过去的十年中，越来越多的证据表明腺苷在帕金森氏病（PD）中起着关键作用，而A2A腺苷受体（A2AARs）在PD中起重要的药理作用。在PD患者的壳膜和外周血细胞中发现了A2AAR的过表达。这项研究的主要目的是验证PD受试者淋巴细胞中A2AAR的变化是否与疾病严重程度相关。材料和方法：连续纳入PD患者样本。进行了临床检查和面对面的采访。研究了A2AAR，以验证淋巴细胞膜中的亲和力和受体密度。将数据与健康对照者的数据进行比较。此外，在PD患者中评估了A2AAR密度和亲和力与临床变量之间的相关性。结果：与健康受试者相比，在PD患者的人淋巴细胞膜中发现A2AAR密度增加，而A2AAR亲和力降低。检测到A2AAR密度或亲和力与运动和认知障碍等特定临床参数之间的统计学显着相关性。 A2AAR密度较高且亲和力较低的患者更容易出现运动并发症。结论：与健康受试者相比，帕金森氏病患者的淋巴细胞膜A2AAR上调。 A2AAR密度或亲和力与临床参数之间的相关性凸显了A2AAR调节在PD药物治疗中的核心作用，并可能暗示了A2AAR作为PD严重程度的候选生物标志物的推定作用。

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