...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Veterinary Research >Host-to-Host Transmission of Streptococcus pneumoniae Is Driven by Its Inflammatory Toxin, Pneumolysin
【24h】

Host-to-Host Transmission of Streptococcus pneumoniae Is Driven by Its Inflammatory Toxin, Pneumolysin

机译：肺炎链球菌的宿主炎症由其炎症毒素，肺炎

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Host-to-host transmission is a critical step for infection. Here we studied transmission of the opportunistic pathogen Streptococcus pneumoniae in an infant mouse model. Transmission from nasally colonized pups required high levels of bacterial shedding in nasal secretions and was temporally correlated with, and dependent upon, the acute inflammatory response. Pneumolysin, a pore-forming cytotoxin and major virulence determinant, was both necessary and sufficient to promote inflammation, which increased shedding and allowed for intralitter transmission. Direct contact between pups was not required for transmission indicating the importance of an environmental reservoir. An additional in vivo effect of pneumolysin was to enhance bacterial survival outside of the host. Our findings provide experimental evidence of a microbial strategy for transit to new hosts and explain why an organism expresses a toxin that damages the host upon which it depends.
机译：主机到主机传输是感染的关键步骤。 在这里，我们研究了在婴儿鼠标模型中的机会主义病原体链球菌的传播。 从鼻息化的幼崽的传递需要在鼻分泌物中的高水平细菌脱落，并且与急性炎症反应的急性炎症反应逐时相关。 肺炎素，形成孔隙形成细胞毒素和主要的毒力决定簇，均是必要的，并且足以促进炎症，增加脱落并允许对管里的传播。 幼崽之间的直接接触不是必需的，表明环境库的重要性。 肺炎素蛋白的体内效果额外是增强宿主外部的细菌存活。 我们的调查结果提供了对新宿主过境的微生物战略的实验证据，并解释了为什么有机体表达毒素，损害其取决于其所取决金的毒素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号