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首页> 外文期刊>American Journal of Ophthalmology: The International Journal of Ophthalmology >Racial Differences in Rate of Change of Spectral-Domain Optical Coherence Tomography–Measured Minimum Rim Width and Retinal Nerve Fiber Layer Thickness
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Racial Differences in Rate of Change of Spectral-Domain Optical Coherence Tomography–Measured Minimum Rim Width and Retinal Nerve Fiber Layer Thickness

机译：谱域光学相干断层扫描变形率变化率的种族差异 - 测量的最小边缘宽度和视网膜神经纤维层厚度

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PurposeTo compare race-related differences in estimated rate of change of Bruch's membrane opening–minimum rim width (BMO-MRW) and circumpapillary retinal nerve fiber layer thickness (RNFLT) in healthy, glaucoma suspect, and glaucoma eyes of individuals of European (ED) and African descent (AD). DesignProspective cohort study. MethodsThis study investigated rate of change of BMO-MRW and RNFLT in 124 healthy, 227 glaucoma suspect, and 177 glaucoma eyes followed for approximately 3 years and tested with optical coherence tomography every 6?months. Suspect eyes had a history of untreated intraocular pressure (IOP) ≥ 22?mm Hgorsuspicion of glaucoma by optic disc photograph assessment without repeatable abnormal standard automated perimetry (SAP) results. Glaucoma eyes had repeatable abnormal SAP results (GHT ONLorPSD ≤ 5%). Mixed-effects models were used to estimate the rate of change after controlling for age, mean follow-up IOP, central corneal thickness, axial length, and BMO area. ResultsA race-related difference in rate of change of global BMO-MRW but not average RNFLT in suspect eyes was observed. Rate of change of BMO-MRW was??1.82?μm/year and??2.20?μm/year in ED and AD suspect eyes, respectively (P?= .03). Rate of change of RNFLT was??0.64?μm/year and??0.75?μm/year in ED and AD suspect eyes, respectively (P?= .75). No race-related differences in change rate were found in healthy or glaucoma eyes. ConclusionRace is an important consideration when assessing structural change, particularly minimum rim width, in glaucoma suspect eyes. Differences in rate of structural change may help explain racial disparities in glaucoma susceptibility.
机译：Puposeto在健康，青光眼嫌疑人和欧洲个人个人（ED）中的青光眼视网膜神经纤维层厚度（RNFlt）和环状的视网膜神经纤维层厚度（RNFLT）的估计变化率的估计变化差异。和非洲血统（广告）。 DesignProspive Cohort研究。方法研究了BMO-MRW和RNFLT的改变率124次健康，227名青光眼嫌疑人和177只青光眼的眼睛，随访约3年并每6个月用光学相干断层扫描测试。怀疑眼睛具有未经治疗的眼内压（IOP）≥22μm的历史，通过光盘照片评估而无可重复的异常标准自动周边（SAP）结果。青光眼的眼睛具有可重复的异常SAP结果（GHTOnlorpsd≤5％）。混合效果模型用于估计控制年龄，平均随访IOP，中央角膜厚度，轴向长度和BMO区域后的变化率。结果观察了全球BMO-MRW的变化率，但不猜到嫌疑人眼睛的平均RNFLT的差异。 BMO-MRW的变化率为1.82？μm/年，并且在ED和AD中/年度/年/年度分别（p？= .03）。 rnflt的变化率为0.64？μm/年，分别为0.75？em-0.75？μm/年，分别是嫌疑人的眼睛（p？= .75）。没有在健康或青光眼的眼睛中发现与变化率的种族相关差异。结论在青光眼评估结构变化，特别是最小rim宽度，青光眼怀疑眼睛的重要考虑因素是一个重要的考虑因素。结构变化率的差异可能有助于解释青光眼易感性的种族差异。

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