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首页> 外文期刊>American journal on intellectual and developmental disabilities: AJIDD >A Novel Framework to Measure Executive Function in Down Syndrome With Applications for Early Clinical Diagnosis of Dementia
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A Novel Framework to Measure Executive Function in Down Syndrome With Applications for Early Clinical Diagnosis of Dementia

机译：一种新的框架，用于测量唐氏综合征的执行功能，具有早期临床诊断痴呆症

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摘要

Executive function (EF) decline is a consistent early sign of Alzheimer's disease (AD) among adults with Down syndrome (DS), which means that baseline measures of EF for individuals with DS are vital to allow detection of meaningful decline. We developed a framework to extract measures of three core components of EF (memory updating, inhibitory, and temporal components) within one task. Increases in memory load, inhibitory load, and temporal demands led to significant increases in reaction times and significant decreases in accuracy among 18 adults with DS and 18 typically developing matched individuals; thus, the expected effects of all three manipulations were detected. Good test-retest reliability indicated that this framework has the potential to provide a simple, baseline EF measure for individuals with DS.
机译：执行功能（EF）下降是Alzheimer疾病（AD）的一致早期征兆（DS）的成年人（DS），这意味着与DS的个体的EF的基线测量对于允许检测有意义的下降至关重要。 我们开发了一个框架，可以在一个任务中提取有三个核心组件的措施的措施。 内存负荷增加，抑制载荷和时间需求导致反应时间的显着增加，18名成人中的18个成人的准确性显着降低，通常是匹配的个体; 因此，检测到所有三种操纵的预期效果。 良好的测试 - 重新测试可靠性表明，该框架有可能为具有DS的个体提供简单的基线EF度量。

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