...
【24h】

Effect of sufentanil on bispectral index in the elderly

机译:苏芬太尼对老年双光谱指数的影响

获取原文
获取原文并翻译 | 示例
           

摘要

We examined the impact of adding sufentanil during anaesthesia induction with propofol on bispectral index values in elderly patients (= 65 years). Patients were randomly assigned to receive a target-controlled sufentanil infusion (effect-site concentration of 0.3 ng.ml(-1)) or matching placebo, followed by a target-controlled propofol induction (initial effect-site concentration of 0.5 mu g.ml(-1); step-wise increase of 0.5 mu g.ml(-1)) until loss of consciousness defined as an Observer's Assessment of Alertness/Sedation score 2. Seventy-one patients (sufentanil 35, placebo 36) completed the study. Mean (SD) age was 72.3 (5.8) years; 41% were women. At loss of consciousness, mean (SD) bispectral index value was 75.0 (8.6) with sufentanil and 70.0 (8.0) with placebo; mean difference -5.0 (95% confidence interval -8.9 to -1.1), p = 0.013. Post-hoc analyses suggest that the difference was significant in men only (mean difference -7.3 (-11.8 to -2.6), p = 0.003). Sufentanil co-induction with propofol results in higher bispectral index values at loss of consciousness in elderly patients.
机译:我们检查了在老年患者中对异β诱导的麻醉诱导过程中加入sufentanil的影响(& = 65岁)。随机分配患者以获得目标控制的苏芬太尼输注(效应 - 部位浓度为0.3ng.ml(-1))或匹配安慰剂,然后进行靶控制的异丙酚诱导(初始效果 - 部位浓度为0.5μg。 ml(-1);逐步增加0.5 mu g.ml(-1)),直到意识丧失被定义为观察者对警觉性/镇静评分的评估2.七十一名患者(Sufentanil 35,安慰剂36)完成了该研究。平均(SD)年龄为72.3(5.8)岁; 41%是女性。在意识丧失时,平均值(SD)双光谱指数值为75.0(8.6),其中Sufentanil和70.0(8.0)与安慰剂;平均差异-5.0(95%置信区间-8.9至-1.1),p = 0.013。后HOC分析表明,差异在男性中是显着的(平均差异-7.3(-11.8至-2.6),p = 0.003)。 Sufentanil与异丙酚的共同诱导导致老年患者的意识丧失的高光谱指标值。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号