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首页> 外文期刊>Acta neurochirurgica.Supplement >Communicating hydrocephalus: the biomechanics of progressive ventricular enlargement revisited.
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Communicating hydrocephalus: the biomechanics of progressive ventricular enlargement revisited.

机译：沟通性脑积水：逐步进行的心室扩大的生物力学。

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BACKGROUND: This article investigates the physical mechanisms involved in the chronic ventricular enlargement that accompanies communicating hydrocephalus (CH)--including its normal and low-pressure forms. In particular, it proposes that this phenomenon can be explained by the combined effect of: (a) a reversal of interstitial fluid flow in the parenchyma, and (b) a reduction in the elastic modulus of the cerebral mantle. METHOD: To investigate this hypothesis, these changes have been incorporated into a finite element computer simulation of CH, in which brain tissue is idealized as a sponge-like material. The fluid pressure in the lateral ventricles and the subarachnoid space has been set to 10 mmHg, while the fluid pressure inside the parenchyma has been set to 7.5 mmHg. The elastic moduli of white and gray matter have been set to the reduced values of 1 and 5 kPa, respectively. FINDINGS: The simulation revealed a substantial ventricular distension (6.5 mm mean outward displacement), which was accompanied by the appearance of stress concentrations in the cerebral mantle. INTERPRETATION: These results support the notion that a relative reduction in intraparenchymal fluid pressure coupled with low tissue elasticity can produce both a significant ventricular enlargement and periventricular solid stress concentrations.
机译：背景：本文研究了与传播性脑积水（CH）伴随的慢性心室扩大所涉及的物理机制，包括其正常形式和低压形式。尤其是，该现象可以用以下综合作用来解释：（a）实质中间质液流动的逆转;（b）脑幔的弹性模量降低。方法：为了研究这一假设，将这些变化纳入了CH的有限元计算机模拟中，其中脑组织被理想化为海绵状材料。侧脑室和蛛网膜下腔中的流体压力已设置为10 mmHg，而实质内的流体压力已设置为7.5 mmHg。白色和灰色物质的弹性模量已分别设置为减小的值1和5 kPa。结果：模拟显示出明显的心室扩张（6.5 mm平均向外移位），并伴有在脑幔中出现应力集中。解释：这些结果支持以下观念，即实质内的体液压力的相对降低与组织弹性低可同时导致明显的心室增大和心室周围固体应力集中。

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