Extracellular Vesicles from Interferon-gamma-primed Human Umbilical Cord Mesenchymal Stromal Cells Reduce Escherichia coli-induced Acute Lung Injury in Rats

Varkouhi Amir K.; Jerkic Mirjana; Ormesher Lindsay; Gagnon Stephane; Goyal Sakshi; Rabani Razieh; Masterson Claire; Spring Chris; Chen Paul Z.; Gu Frank X.; dos Santos Claudia C.; Curley Gerard F.; Laffey John G.

首页> 外文期刊>Anesthesiology >Extracellular Vesicles from Interferon-gamma-primed Human Umbilical Cord Mesenchymal Stromal Cells Reduce Escherichia coli-induced Acute Lung Injury in Rats

【24h】

Extracellular Vesicles from Interferon-gamma-primed Human Umbilical Cord Mesenchymal Stromal Cells Reduce Escherichia coli-induced Acute Lung Injury in Rats

机译：来自干扰素 - γ-灌注的人脐部间充质细胞间充质细胞的细胞外囊降低大鼠大肠杆菌诱导的大鼠急性肺损伤

获取原文

获取原文并翻译 | 示例

获取外文期刊封面封底 >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Background: Human umbilical cord mesenchymal stromal cells possess considerable therapeutic promise for acute respiratory distress syndrome. Umbilical cord mesenchymal stromal cells may exert therapeutic effects via extracellular vesicles, while priming umbilical cord mesenchymal stromal cells may further enhance their effect. The authors investigated whether interferon-gamma-primed umbilical cord mesenchymal stromal cells would generate mesenchymal stromal cell-derived extracellular vesicles with enhanced effects in Escherichia coli (E. coli) pneumonia.

机译：背景：人脐部间充质基质细胞对急性呼吸窘迫综合征具有相当大的治疗承诺。脐带间充质基质细胞可以通过细胞外囊泡施加治疗作用，同时引发脐带间充质基质细胞可能进一步增强它们的作用。作者研究了干扰素 - γ-灌注脐带间充质细胞间质细胞是否会产生间充质基质细胞衍生的细胞内囊泡，其在大肠杆菌（大肠杆菌）肺炎中具有增强的效果。

著录项

来源
《Anesthesiology》 |2019年第5期|共13页
作者
Varkouhi Amir K.; Jerkic Mirjana; Ormesher Lindsay; Gagnon Stephane; Goyal Sakshi; Rabani Razieh; Masterson Claire; Spring Chris; Chen Paul Z.; Gu Frank X.; dos Santos Claudia C.; Curley Gerard F.; Laffey John G.;
展开▼
作者单位

Univ Toronto St Michaels Hosp Keenan Res Ctr Biomed Sci Toronto ON Canada;

Univ Toronto St Michaels Hosp Keenan Res Ctr Biomed Sci Toronto ON Canada;

Univ Toronto St Michaels Hosp Keenan Res Ctr Biomed Sci Toronto ON Canada;

Univ Toronto St Michaels Hosp Keenan Res Ctr Biomed Sci Toronto ON Canada;

Univ Toronto St Michaels Hosp Keenan Res Ctr Biomed Sci Toronto ON Canada;

Univ Toronto St Michaels Hosp Keenan Res Ctr Biomed Sci Toronto ON Canada;

Univ Toronto St Michaels Hosp Keenan Res Ctr Biomed Sci Toronto ON Canada;

Univ Toronto St Michaels Hosp Keenan Res Ctr Biomed Sci Toronto ON Canada;

Univ Waterloo Waterloo Inst Nanotechnol Dept Chem Engn Waterloo ON Canada;

Univ Toronto Dept Chem Engn &

Appl Chem Toronto ON Canada;

Univ Toronto St Michaels Hosp Keenan Res Ctr Biomed Sci Toronto ON Canada;

Univ Toronto St Michaels Hosp Keenan Res Ctr Biomed Sci Toronto ON Canada;

Univ Toronto St Michaels Hosp Keenan Res Ctr Biomed Sci Toronto ON Canada;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类麻醉学;
关键词

相似文献

外文文献
中文文献
专利

1. Extracellular Vesicles from Interferon-gamma-primed Human Umbilical Cord Mesenchymal Stromal Cells Reduce Escherichia coli-induced Acute Lung Injury in Rats [J] . Varkouhi Amir K., Jerkic Mirjana, Ormesher Lindsay, Anesthesiology . 2019,第5期

机译：来自干扰素 - γ-灌注的人脐部间充质细胞间充质细胞的细胞外囊降低大鼠大肠杆菌诱导的大鼠急性肺损伤
2. Extracellular membrane vesicles from umbilical cord blood derived mesenchymal stromal cells protect against ischemic acute kidney injury, a feature that is lost after inflammatory conditioning [J] . Kilpinen L., Impola U., Sankkila L., Human gene therapy . 2015,第10期

机译：来自脐带血液血液源性间充质基质细胞的细胞外膜囊泡可保护缺血性急性肾损伤，炎症调节后损失的特征
3. Circular RNA Involvement in the Protective Effect of Human Umbilical Cord Mesenchymal Stromal Cell-Derived Extracellular Vesicles Against Hypoxia/Reoxygenation Injury in Cardiac Cells [J] . Changyi Zhang, Hongwu Wang, Jilin Li, Frontiers in Cardiovascular Medicine . 2021,第a期

机译：圆形RNA参与人脐部间充质基质细胞衍生细胞内囊泡免受心脏细胞缺氧/雷诺损伤的保护作用
4. SCALABLE EXPANSION OF HUMAN UMBILICAL CORD MATRIX- AND ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM/STROMAL CELLS AND DERIVED EXOSOMES IN THE SINGLE-USE, VERTICAL-WHEEL BIOREACTOR SYSTEM USING A HUMAN PLATELET LYSATE CULTURE SUPPLEMENT [C] . Ana Fernandes-Platzgummer, Diogo de Sousa Pinto, Miguel de Almeida Fuzeta, Conference on advancing manufacture of cell and gene therapies . 2019

机译：单次使用垂直轮生物反应器系统中人类脐带基质和脂肪组织来源的间充质干细胞/基质细胞和衍生的外来体的可扩展性，使用人类血小板裂解液培养物
5. Adenoviral Mediated Gene Delivery to Human Umbilical Cord Mesenchymal Stromal Cells for Inner Ear Hair Cell Differentiation. [D] . Devarajan, Keerthana. 2011

机译：腺病毒介导的基因传递到人脐带间质基质细胞内耳毛细胞分化。
6. Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells attenuates Escherichia coli-induced acute lung injury in mice [O] . Eun Sun Kim, Yun Sil Chang, Soo Jin Choi, 2011

机译：人脐带血间充质干细胞气管内移植可减轻大肠杆菌诱导的小鼠急性肺损伤
7. Extracellular Vesicles from Interferon-γ–primed Human Umbilical Cord Mesenchymal Stromal Cells Reduce Escherichia coli–induced Acute Lung Injury in Rats [O] . Amir K. Varkouhi, Mirjana Jerkic, Lindsay Ormesher, 2019

机译：来自干扰素-γ-灌注的人脐带间充质细胞间充质细胞的细胞外囊泡降低了大鼠大肠杆菌诱导的大鼠急性肺损伤

Extracellular Vesicles from Interferon-gamma-primed Human Umbilical Cord Mesenchymal Stromal Cells Reduce Escherichia coli-induced Acute Lung Injury in Rats

摘要

著录项

相似文献

相关主题

期刊订阅