L-arginine and Arginase Products Potentiate Dexmedetomidine-induced Contractions in the Rat Aorta

Wong Emily S. W.; Man Ricky Y. K.; Ng Kwok F. J.; Leung Susan W. S.; Vanhoutte Paul M.

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L-arginine and Arginase Products Potentiate Dexmedetomidine-induced Contractions in the Rat Aorta

机译：L-精氨酸和精氨酸酶产品具有促进的右甲甲基甲基诱导的大鼠主动脉的收缩

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Background: The alpha(2)-adrenergic sedative/anesthetic agent dexmedetomidine exerts biphasic effects on isolated arteries, causing endothelium-dependent relaxations at concentrations at or below 30 nM, followed by contractions at higher concentrations. L-arginine is a common substrate of endothelial nitric oxide synthase and arginases. This study was designed to investigate the role of L-arginine in modulating the overall vascular response to dexmedetomidine.

机译：背景：α（2） - 肾上腺素能沉积物/麻醉剂Dexmedetomidine对孤立的动脉施加双色作用，在30nm处或低于30nm的浓度下引起内皮依赖性弛豫，然后在较高浓度下进行收缩。 L-精氨酸是内皮一氧化氮合酶和酶学酶的常见基质。本研究旨在探讨L-精氨酸在调节对德Xmedetomidine的整体血管反应方面的作用。

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《Anesthesiology》 |2018年第3期|共10页
作者
Wong Emily S. W.; Man Ricky Y. K.; Ng Kwok F. J.; Leung Susan W. S.; Vanhoutte Paul M.;
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作者单位

Open Univ Hong Kong Sch Sci &

Technol Appl Sci &

Environm Studies Kowloon Hong Kong Peoples R;

Univ Hong Kong State Key Lab Pharmaceut Biotechnol Pokfulam Hong Kong Peoples R China;

Univ Hong Kong State Key Lab Pharmaceut Biotechnol Pokfulam Hong Kong Peoples R China;

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正文语种 eng
中图分类麻醉学;
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1. L-arginine and Arginase Products Potentiate Dexmedetomidine-induced Contractions in the Rat Aorta [J] . Wong Emily S. W., Man Ricky Y. K., Ng Kwok F. J., Anesthesiology . 2018,第3期

机译：L-精氨酸和精氨酸酶产品具有促进的右甲甲基甲基诱导的大鼠主动脉的收缩
2. Dexmedetomidine-induced contraction involves c-Jun NH2-terminal kinase phosphorylation through activation of the 5-lipoxygenase pathway in the isolated endothelium-denuded rat aorta [J] . Clinical and experimental pharmacology & physiology . 2014,第12期

机译：右美托咪定诱导的收缩涉及通过分离内皮剥除的大鼠主动脉中的5-脂氧合酶途径的激活，使c-Jun NH 2 -末端激酶磷酸化
3. Dexmedetomidine-induced Contraction Involves Phosphorylation of Caldesmon by JNK in Endothelium-denuded Rat Aortas [J] . Jiseok Baik, Seong-Ho Ok, Hyunhoo Cho, International journal of biological sciences . 2014,第10期

机译：右美托咪定诱导的收缩涉及JNK在内皮剥除的大鼠主动脉中被卡尔德斯蒙磷酸化。
4. The effects of chronic AC magnetic field on contraction and relaxation of isolated thoracic aorta rings of healthy and diabetic rats [C] . Ocal I., Demirkazik A., Emre M., Electromagnetic Compatibility, 2003. EMC '03. 2003 IEEE International Symposium on . 2003

机译：慢性交流磁场对健康和糖尿病大鼠离体胸主动脉环收缩和舒张的影响
5. Mechanism of augmented alpha 2 adrenergic receptor contraction in aorta from chronic nitric oxide synthase inhibited hypertensive rats. [D] . Carter, Rebecca W. 2002

机译：慢性一氧化氮合酶抑制的高血压大鼠主动脉中α2肾上腺素能受体收缩增强的机制。
6. Dexmedetomidine-induced contraction of isolated rat aorta is dependent on extracellular calcium concentration [O] . Seong-Ho Ok, Sung Il Bae, Haeng Seon Shim, 2012

机译：右美托咪定诱导的离体大鼠主动脉收缩取决于细胞外钙浓度
7. Dexmedetomidine-induced contraction of isolated rat aorta is dependent on extracellular calcium concentration [O] . Seong-Ho Ok, Sung Il Bae, Haeng Seon Shim, 2012

机译：Dexmedetomidine诱导分离的大鼠主动脉收缩依赖于细胞外钙浓度
8. Phorbol Esters Inhibit Alpha-Adrenergic Receptor-Stimulated Phosphoinositide Hydrolysis and Contraction in Rat Aorta: Evidence for a Link between Vascular Contraction and Phosphoinositide Turnover [R] . McMillan, M., Chernow, B., Roth, B. L. 1986

机译：佛波酯抑制大鼠主动脉α-肾上腺素能受体刺激的磷酸肌醇水解和收缩：血管收缩与磷脂酰肌醇周转之间联系的证据

L-arginine and Arginase Products Potentiate Dexmedetomidine-induced Contractions in the Rat Aorta

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