Antifibrinolytic Therapy and Perioperative Considerations

Levy Jerrold H.; Koster Andreas; Quinones Quintin J.; Milling Truman J.; Key Nigel S.

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Antifibrinolytic Therapy and Perioperative Considerations

机译：抗纤维蛋白溶解治疗和围手术期考虑因素

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Fibrinolysis is a physiologic component of hemostasis that functions to limit clot formation. However, after trauma or surgery, excessive fibrinolysis may contribute to coagulopathy, bleeding, and inflammatory responses. Antifibrinolytic agents are increasingly used to reduce bleeding, allogeneic blood administration, and adverse clinical outcomes. Tranexamic acid is the agent most extensively studied and used in most countries. This review will explore the role of fibrinolysis as a pathologic mechanism, review the different pharmacologic agents used to inhibit fibrinolysis, and focus on the role of tranexamic acid as a therapeutic agent to reduce bleeding in patients after surgery and trauma.

机译：纤维蛋白溶解是止血的生理成分，其用于限制凝块形成。然而，在创伤或手术后，过量的纤维蛋白溶解可能有助于凝结病，出血和炎症反应。越抗纤维蛋白溶剂越来越多地用于减少出血，同种异体血液给药和不良临床结果。 Tranexamic acid是大多数国家最广泛研究和使用的药剂。本综述将探讨纤维蛋白溶解作为病理机制的作用，审查用于抑制纤维蛋白溶解的不同药理剂，并专注于宁酸作为治疗剂的作用，以减少手术和创伤后患者出血。

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《Anesthesiology》 |2018年第3期|共14页
作者
Levy Jerrold H.; Koster Andreas; Quinones Quintin J.; Milling Truman J.; Key Nigel S.;
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作者单位

Duke Univ Sch Med Dept Anesthesiol Div Cardiothorac Anesthesiol &

Crit Care Durham NC USA;

Ruhr Univ Bochum Inst Anesthesiol Heart &

Diabet Ctr North Rhine Westphalia Bad Oey Bochum;

Duke Univ Sch Med Dept Anesthesiol Div Cardiothorac Anesthesiol &

Crit Care Durham NC USA;

Stroke Inst Seton Dell Med Sch Austin TX USA;

Univ N Carolina Dept Med Div Hematol Oncol Chapel Hill NC USA;

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正文语种 eng
中图分类麻醉学;
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1. Antifibrinolytic Therapy and Perioperative Considerations [J] . Levy Jerrold H., Koster Andreas, Quinones Quintin J., Anesthesiology . 2018,第3期

机译：抗纤维蛋白溶解治疗和围手术期考虑因素
2. Perioperative and Anesthetic Considerations for Neurosurgical Laser Interstitial Thermal Therapy Ablations [J] . Jimenez-Ruiz Federico, Arnold Benjamin, Tatsui Claudio E., Journal of neurosurgical anesthesiology . 2018,第1期

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3. Perioperative Considerations for the Patient with Opioid Use Disorder on Buprenorphine, Methadone, or Naltrexone Maintenance Therapy [J] . Thomas Kyle Harrison, Howard Kornfeld, Anuj Kailash Aggarwal, Anesthesiology clinics . 2018,第3期

机译：对丁丙诺啡，美沙酮或纳曲酮维持治疗的阿片类药物使用疾病的围手术期考虑因素
4. Monitoring of Perioperative Ventilation Therapy by Electrical Impedance Tomography (EIT) in Clinical Practice [C] . J. Karsten, A. Jedmowski, H. Luepschen, World congress on medical physics and biomedical engineering;International congress of the IUPESM . 2011

机译：在临床实践中通过电阻抗断层扫描（EIT）监测围手术期通气治疗
5. Use and effectiveness of perioperative cardiac medical therapy among patients undergoing coronary artery bypass graft surgery [D] . Filion, Kristian B. 2006

机译：冠状动脉旁路移植手术患者围手术期心脏医学治疗的使用和有效性
6. Antifibrinolytic Therapy and Perioperative Considerations [O] . Jerrold H. Levy, Andreas Koster, Quintin J. Quinones, -1

机译：抗纤溶治疗和围手术期注意事项
7. Practical considerations in antifibrinolytic therapy. [O] . R Hart, B Coull 1982

机译：防纤维蛋白溶解治疗的实践考虑。

Antifibrinolytic Therapy and Perioperative Considerations

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