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首页> 外文期刊>Analytical Letters >Minireview: Trends in Optical-Based Biosensors for Point-Of-Care Bacterial Pathogen Detection for Food Safety and Clinical Diagnostics
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Minireview: Trends in Optical-Based Biosensors for Point-Of-Care Bacterial Pathogen Detection for Food Safety and Clinical Diagnostics

机译：MINIREVIEW：用于食品安全和临床诊断的护理点细菌病原体检测的光学生物传感器的趋势

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摘要

This review considers the evolution of optical-based biosensors for bacterial pathogen detection as the causative agents for different diseases. Conventional identification and detection techniques are tedious, expensive and time-consuming, typically requiring sample pretreatment and hours to days to provide the results. For the successful monitoring of bacterial pathogen infection, fast, accurate, cost-effective and reliable techniques to simultaneously detect multiple bacterial pathogens and microbial metabolites are of the utmost importance in fields such as the food industry and healthcare. In addition, miniaturized, small amount of sample, easy to use with minimal accessories, and portable device should take advantage for rapid and point-of-care (POC) diagnosis. Optical transduction plays a substantial character in the development of such miniaturized and integrated biosensors as the alternatives to conventional analytical methods. In this review, we consider trends in point-of-care bacterial pathogen detection, different biorecognition elements, immobilization techniques, and optical based transduction methods applied for bacterial pathogen detection along with the respective advantages and drawbacks of each technique. Moreover, some examples of recently reported techniques for point-of-care analysis are also discussed. The analytical performance and characteristics of an ideal biosensor are discussed based on literature biosensor descriptions.
机译：该综述考虑了用于细菌病原体检测的光学生物传感器的演变作为不同疾病的致病剂。常规识别和检测技术具有繁琐的，昂贵且耗时，通常需要样品预处理和数小时以提供结果。为了成功监测细菌病原体感染，快速，准确，成本效益和可靠的技术，可同时检测多种细菌病原体和微生物代谢物在食品工业和医疗保健等领域至关重要。此外，小型化，少量样品，易于使用的材料，便携式设备应利用快速和护理点（POC）诊断。光学转导在这种小型化和整合的生物传感器的发展中起到实质性的特征，作为常规分析方法的替代品。在本文中，我们考虑施加用于细菌病原体检测的小组细菌病原体检测，不同生物认知元素，固定化技术和光学转导方法的趋势以及每种技术的各个优点和缺点。此外，还讨论了最近报告了用于护理点分析技术的一些示例。基于文献生物传感器描述讨论了理想生物传感器的分析性能和特征。

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