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首页> 外文期刊>Annals of anatomy =: Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft >Comparative postnatal histomorphogenesis of the mandible in wild and laboratory mice
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Comparative postnatal histomorphogenesis of the mandible in wild and laboratory mice

机译：野生和实验室小鼠中颌骨的比较产后组织组织

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The coordinated activity of bone cells (i.e., osteoblasts and osteoclasts) during ontogeny underlies observed changes in bone growth rates (recorded in bone histology and bone microstructure) and bone remodeling patterns explaining the ontogenetic variation in bone size and shape. Histological cross sections of the mandible in the C57BL/6J inbred mouse strain were recently examined in order to analyze the bone microstructure, as well as the directions and rates of bone growth according to the patterns of fluorescent labeling, with the aim of description of the early postnatal histomorphogenesis of this skeletal structure. Here we use the same approach to characterize the histomorphogenesis of the mandible in wild specimens of Mus musculus domesticus, from the second to the eighth week of postnatal life, for the first time. In addition, we assess the degree of similarity in this biological process between the wild specimens examined and the C57BL/6J laboratory strain. Bone microstructure data show that M. musculus domesticus and the C57BL/6J strain differ in the temporospatial pattern of histological maturation of the mandible, which particularly precludes the support of mandibular organization into the alveolar region and the ascending ramus modules at the histological level in M. musculus domesticus. The patterns of fluorescent labeling reveal that the mandible of the wild mice exhibits temporospatial differences in the remodeling pattern, as well as higher growth rates particularly after weaning, compared to the laboratory mice. Since the two mouse groups were reared under the same conditions, the dissimilarities found suggest the existence of differences between the groups in the genetic regulation of bone remodeling, probably as a result of their different genetic backgrounds. Despite the usual suitability of inbred mouse strains as model organisms, inferences from them to natural populations regarding bone growth should be made with caution. (C) 2017 Elsevier GmbH. All rights reserved.
机译：在脑发生下的骨细胞（即，成骨细胞和骨细胞）的协调活性观察到骨生长速率的变化（记录在骨组织学和骨微观结构中）和骨改造模式，解释骨骼尺寸和形状的植入变异。最近检查了C57BL / 6J近交小鼠菌株中下颌骨的组织学横截面，以分析骨微观结构，以及根据荧光标记的图案分析骨骼微观结构，以及骨骼生长的方向和速率，目的是描述这种骨骼结构的早期产后组织组织组织组织。在这里，我们使用相同的方法来表征血液肌肉样本中下颌骨的组织组织组织，从第二次到后期生命的第二个星期，第一次。此外，我们评估了在检查的野生标本和C57BL / 6J实验室菌株之间的这种生物过程中的相似性。骨微观结构数据显示，M. Masculus Domanderus和C57BL / 6J菌株在下颌骨组织学成熟的时间间隙模式中不同，这尤其排除了下颌组织在肺泡区和升序中的升序中的升序模块。肌肉管家。荧光标记的图案表明，与实验室小鼠相比，野生小鼠的下颌骨表现出重塑模式的间质差异，以及较高的生长速率，与实验室小鼠相比。由于在相同条件下饲养了两种小鼠基团，所以发现的差异表明，可能是由于其不同的遗传背景的骨质重塑遗传调节中的群体之间存在差异。尽管近额鼠标菌株作为模型生物的常规适用性，但应谨慎地从其对骨骼生长的天然群体的推论。 （c）2017 Elsevier GmbH。版权所有。

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