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首页> 外文期刊>Annals of anatomy =: Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft >Distribution and neurochemistry of porcine urinary bladder-projecting sensory neurons in subdomains of the dorsal root ganglia: A quantitative analysis
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Distribution and neurochemistry of porcine urinary bladder-projecting sensory neurons in subdomains of the dorsal root ganglia: A quantitative analysis

机译：背根神经细胞亚域内猪尿膀胱突出的感觉神经元的分布和神经化学分析：定量分析

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摘要

The aim of the present study has been to verify the inter-and intraganglionic distribution pattern of porcine urinary bladder-projecting (UBP) neurons localized in the sacral dorsal root ganglia (DRGs). The morphology and chemical phenotype of these cells have also been investigated. These neurons were visualized using the fluorescent tracer Fast Blue (FB) which was injected bilaterally into the urinary bladder wall of five juvenile female pigs. The intraganglionic distribution showed that small- and medium-sized FB+ perikarya were mainly located in the central (S-3-S-4) and periphero-central (S-2) region of the ganglia, while large cells were heterogeneously distributed. Immunohistochemistry revealed that the most frequently observed markers in small and medium-sized UBP perikarya were: neurofilament 200,lectin from Bandeiraea simplicifolia (Griffonia simplicifolia) isolectin B4, substance P, calcitonin gene-related peptide, pituitary adenylate cyclase-activating polypeptide and transient receptor potential vanilloid 1. Moreover, UBP neurons containing these substances were also mainly observed in the central and periphero-central region of the ganglion. Differences in the percentage of traced cells and their neuropeptide content were observed between the S-2, S-3 and S-4 DRGs. In conclusion, the present study, for the first time, describes the arrangement of UBP DRGs neurons within particular subdomains of sacral ganglia, taking into account their size and chemical phenotype. (C) 2017 Elsevier GmbH. All rights reserved.
机译：本研究的目的是验证猪膀胱膀胱突出（UBP）神经元（UBP）神经元（UBP）神经元（DRGS）局部化的跨性和Intranganglion分布模式。还研究了这些细胞的形态和化学表型。使用荧光示踪剂快蓝（FB）可视化这些神经元，其双侧注射到五个幼年母猪的尿膀胱壁中。 IntrAragnlionic分布表明，小型和中型FB + Perikarya主要位于神经节的中央（S-3-S-4）和周围中央（S-2）区域，而大细胞是异质分布的。免疫组织化学显示，中小型UBP Perikarya中最常观察到的标记是：神经束200，来自Bandeiraea的凝集素（Griffonia SimpleColia）二胞蛋白B4，物质p，降钙素相关肽，垂体腺苷酸环酶激活多肽和瞬态受体此外，含有这些物质的UBP神经元在神经节的中央和周围中心地区也主要观察到含有这些物质的UBP神经元。在S-2，S-3和S-4 DRG之间观察到跟踪细胞百分比及其神经肽含量的差异。总之，本研究首次描述了UBP DRGS神经元在骶神经节特定亚域内的安排，考虑到其大小和化学表型。 （c）2017 Elsevier GmbH。版权所有。

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