Randomised controlled trial comparing efficacy of same day administration of mifepristone and misoprostol for termination of pregnancy with the standard 36- to 48-hour protocol.

Guest J; Chien P; Thomson M; Kosseim ML

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Randomised controlled trial comparing efficacy of same day administration of mifepristone and misoprostol for termination of pregnancy with the standard 36- to 48-hour protocol.

机译：随机对照试验比较了米非司酮和米索前列醇当日给药与标准36至48小时方案终止妊娠的疗效。

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Hypothesis That a 6-hour drug administration interval has similar efficacy and greater patient satisfaction as a 36- to 48-hour interval. Sample Four hundred and fifty patients. Methods A two-arm parallel design unblended randomised controlled trial in a single hospital. Eligible women up to 63 days of gestation will be invited to participate. Those willing will be randomised to either the experimental group (6 hours administration of misoprostol) or the control group (36-48 hours administration of misoprostol). All participants will take 200 mg mifepristone orally. At the time determined by study group allocation 800 mug misoprostol will be given intravaginally together with 100 mg diclofenac pr. Antibiotic prophylaxis as per the usual protocol will be given to each group. The control group will remain in hospital for 6 hours as per current policy and the study group will return home in 1 to 3 hours. Main outcome measure Complete medical abortion without need for further misoprostol or surgical evacuation. Secondary outcomes Duration of bleeding, side effects and acceptability based on questionnaire. Funding Source None.

机译：假设6个小时的给药间隔与36到48个小时的间隔具有相似的疗效和更高的患者满意度。样本450名患者。方法在一家医院进行两臂平行设计的无混合随机对照试验。长达63天的合格女性将被邀请参加。那些愿意的患者将被随机分为实验组（米索前列醇6小时）或对照组（米索前列醇36-48小时）。所有参与者将口服200毫克米非司酮。在研究组确定的时间点，将阴道内给予800杯米索前列醇与100 mg双氯芬酸pr。每组将按照常规方案进行抗生素预防。根据现行政策，对照组将在医院停留6个小时，研究组将在1-3个小时内返回家中。主要结果衡量指标完全的医学流产，无需进一步的米索前列醇或手术后撤离。次要结果根据问卷调查，出血持续时间，副作用和可接受性。资金来源无。

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《BJOG: an international journal of obstetrics and gynaecology》 |2005年第10期|共1页
作者
Guest J; Chien P; Thomson M; Kosseim ML;
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正文语种 eng
中图分类妇产科学;
关键词
Hour; Misoprostol; Protocols documentation; Mifepristone; Pregnancy loss; 米索前列醇; 米非司酮;

机译：Hour;Misoprostol;Protocols documentation;Mifepristone;Pregnancy loss;米索前列醇;米非司酮;

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1. Randomised controlled trial comparing efficacy of same day administration of mifepristone and misoprostol for termination of pregnancy with the standard 36- to 48-hour protocol. [J] . Guest J, Chien P, Thomson M, BJOG: an international journal of obstetrics and gynaecology . 2005,第10期

机译：随机对照试验比较了米非司酮和米索前列醇当日给药与标准36至48小时方案终止妊娠的疗效。
2. Efficacy of mifepristone followed on the same day by misoprostol for early termination of pregnancy: report of a randomised trial. [J] . Creinin MD, Schwartz JL, Pymar HC, BJOG: an international journal of obstetrics and gynaecology . 2001,第5期

机译：米非司酮的疗效在同一天之后是米索前列醇，用于提前终止妊娠：一项随机试验的报告。
3. Two mifepristone doses and two intervals of misoprostol administration for termination of early pregnancy: a randomised factorial controlled equivalence trial. [J] . von-Hertzen H, Piaggio G, Wojdyla D, BJOG: an international journal of obstetrics and gynaecology . 2009,第3期

机译：两次米非司酮剂量和两次米索前列醇给药间隔以终止早孕：一项随机因数对照等效试验。
4. The best evidence: A randomised controlled trial to assess the efficacy of a nutraceutical to treat headshaking [C] . Gina L. Pinchbeck British Equine Veterinary Association Congress . 2009

机译：最好的证据：随机对照试验，以评估营养保健治疗耳机的功效
5. A randomized controlled trial to evaluate the use of misoprostol for second trimester pregnancy termination associated with fetal malformation. [D] . Akoury, Hani Albert. 2002

机译：一项评估米索前列醇用于终止与胎儿畸形相关的孕中期妊娠的随机对照试验。
6. Mifepristone followed by misoprostol compared with placebo followed by misoprostol as medical treatment for early pregnancy loss (the Triple M trial): A double-blind placebo-controlled randomised trial [O] . Charlotte Hamel, Sjors Coppus, Joyce van den Berg, 2021

机译：米非司酮随后与安慰剂相比与安慰剂相比米索多醇作为早期妊娠损失的医疗（Triple M试验）：双盲安慰剂随机试验
7. Randomised controlled trial comparing the efficacy of same-day administration of mifepristone and misoprostol for termination of pregnancy with the standard 36 to 48 hour protocol [O] . Guest J, Chien P F W, Thomson M A R, 2007

机译：随机对照试验比较了米非司酮和米索前列醇当日给药与标准36到48小时方案对终止妊娠的疗效

Randomised controlled trial comparing efficacy of same day administration of mifepristone and misoprostol for termination of pregnancy with the standard 36- to 48-hour protocol.

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