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首页> 外文期刊>Andrologia >Effect of orchiectomy on sperm functional aspects and semen oxidative stress in men with testicular tumours
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Effect of orchiectomy on sperm functional aspects and semen oxidative stress in men with testicular tumours

机译：睾丸切除术对睾丸肿瘤男性精子功能方面和精液氧化应激的影响

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Abstract To verify if quality of spermatozoa from men with testicular germ cell tumours is better before or after orchiectomy. This prospective study was carried out including 24 patients with testicular germ cell tumours, who provide one semen sample before they were submitted to unilateral orchiectomy and one other semen sample 30?days after the surgery. After collection by masturbation and liquefaction, an aliquot of the semen sample was used for semen analysis and another was used to evaluate sperm mitochondrial activity, DNA fragmentation and acrosome integrity. Seminal plasma was used to evaluate lipid peroxidation levels. Pre‐orchiectomy sample and post‐orchiectomy sample were compared using a paired Student's t test (normal distribution) or a paired Wilcoxon test, when appropriate ( p ???0.05). No significant difference was observed in semen analysis. A significant decrease in DNA fragmentation and lipid peroxidation and an increase in mitochondrial activity were observed after orchiectomy. Based on our findings, the semen quality from men with testicular germ cell tumours is better after orchiectomy.
机译：摘要为了验证来自睾丸生殖细胞肿瘤的男性的精子质量是否在睾丸切除术前或之后更好。进行该前瞻性研究，包括24例睾丸生殖细胞瘤患者，在手术后向单侧睾丸切除术和另一项精液样品中提供一个精液样本。在通过手淫和液化收集后，用于精液样品的等分试样用于精液分析，另一个用于评估精子线粒体活性，DNA碎片和副型完整性。使用精血浆来评估脂质过氧化水平。使用配对的学生的T试验（正态分布）或配对的Wilcoxon试验进行比较核切除术样品和睾丸切除术样品（P ??? 0.05）。精液分析中没有观察到显着差异。睾丸切除术后，观察到DNA碎片和脂质过氧化的显着降低和线粒体活性的增加。基于我们的研究结果，睾丸切除术后，来自睾丸生殖细胞瘤的男性的精液质量更好。

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