Magnetic Resonance Spectroscopy as a Tool for Assessing Macromolecular Structure and Function in Living Cells

Li Conggang; Zhao Jiajing; Cheng Kai; Ge Yuwei; Wu Qiong; Ye Yansheng; Xu Guohua; Zhang Zeting; Zheng Wenwen; Zhang Xu; Zhou Xin; Pielak Gary; Liu Maili

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Magnetic Resonance Spectroscopy as a Tool for Assessing Macromolecular Structure and Function in Living Cells

机译：磁共振光谱作为评估大分子结构和活细胞功能的工具

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Investigating the structure, modification, interaction, and function of biomolecules in their native cellular environment leads to physiologically relevant knowledge about their mechanisms, which will benefit drug discovery and design. In recent years, nuclear and electron magnetic resonance (NMR) spectroscopy has emerged as a useful tool for elucidating the structure and function of biomacromolecules, including proteins, nucleic acids, and carbohydrates in living cells at atomic resolution. In this review, we summarize the progress and future of in-cell NMR as it is applied to proteins, nucleic acids, and carbohydrates.

机译：研究生物分子在原生细胞环境中的结构，修改，相互作用和功能导致对其机制的生理相关知识，这将使药物发现和设计受益。近年来，核和电子磁共振（NMR）光谱已成为一种有用的工具，用于在原子分辨率下阐明生物致摩托（包括蛋白质，核酸和碳水化合物）在原子分辨率下的生物群体的结构和功能。在本综述中，我们总结了细胞内NMR的进展和未来，因为它适用于蛋白质，核酸和碳水化合物。

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来源
《Annual Review of Analytical Chemistry》 |2017年第2017期|共26页
作者
Li Conggang; Zhao Jiajing; Cheng Kai; Ge Yuwei; Wu Qiong; Ye Yansheng; Xu Guohua; Zhang Zeting; Zheng Wenwen; Zhang Xu; Zhou Xin; Pielak Gary; Liu Maili;
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作者单位

Chinese Acad Sci Key Lab Magnet Resonance &

Atom &

Mol Phys Key Lab Magnet Resonance Biol Syst Natl Ctr Magnet Resonance Wuhan Inst Phys &

Math Wuhan 430071 Peoples R China;

Chinese Acad Sci Key Lab Magnet Resonance &

Atom &

Mol Phys Key Lab Magnet Resonance Biol Syst Natl Ctr Magnet Resonance Wuhan Inst Phys &

Math Wuhan 430071 Peoples R China;

Chinese Acad Sci Key Lab Magnet Resonance &

Atom &

Mol Phys Key Lab Magnet Resonance Biol Syst Natl Ctr Magnet Resonance Wuhan Inst Phys &

Math Wuhan 430071 Peoples R China;

Chinese Acad Sci Key Lab Magnet Resonance &

Atom &

Mol Phys Key Lab Magnet Resonance Biol Syst Natl Ctr Magnet Resonance Wuhan Inst Phys &

Math Wuhan 430071 Peoples R China;

Chinese Acad Sci Key Lab Magnet Resonance &

Atom &

Mol Phys Key Lab Magnet Resonance Biol Syst Natl Ctr Magnet Resonance Wuhan Inst Phys &

Math Wuhan 430071 Peoples R China;

Chinese Acad Sci Key Lab Magnet Resonance &

Atom &

Mol Phys Key Lab Magnet Resonance Biol Syst Natl Ctr Magnet Resonance Wuhan Inst Phys &

Math Wuhan 430071 Peoples R China;

Chinese Acad Sci Key Lab Magnet Resonance &

Atom &

Mol Phys Key Lab Magnet Resonance Biol Syst Natl Ctr Magnet Resonance Wuhan Inst Phys &

Math Wuhan 430071 Peoples R China;

Chinese Acad Sci Key Lab Magnet Resonance &

Atom &

Mol Phys Key Lab Magnet Resonance Biol Syst Natl Ctr Magnet Resonance Wuhan Inst Phys &

Math Wuhan 430071 Peoples R China;

Chinese Acad Sci Key Lab Magnet Resonance &

Atom &

Mol Phys Key Lab Magnet Resonance Biol Syst Natl Ctr Magnet Resonance Wuhan Inst Phys &

Math Wuhan 430071 Peoples R China;

Chinese Acad Sci Key Lab Magnet Resonance &

Atom &

Mol Phys Key Lab Magnet Resonance Biol Syst Natl Ctr Magnet Resonance Wuhan Inst Phys &

Math Wuhan 430071 Peoples R China;

Chinese Acad Sci Key Lab Magnet Resonance &

Atom &

Mol Phys Key Lab Magnet Resonance Biol Syst Natl Ctr Magnet Resonance Wuhan Inst Phys &

Math Wuhan 430071 Peoples R China;

Univ N Carolina Dept Chem Dept Biochem &

Biophys Chapel Hill NC 27599 USA;

Chinese Acad Sci Key Lab Magnet Resonance &

Atom &

Mol Phys Key Lab Magnet Resonance Biol Syst Natl Ctr Magnet Resonance Wuhan Inst Phys &

Math Wuhan 430071 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类物理化学计量;
关键词
in-cell NMR; protein structure; posttranslational modification; protein interaction; RNA;

机译：细胞内NMR;蛋白质结构;后期改性;蛋白质相互作用;RNA;

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1. Magnetic Resonance Spectroscopy as a Tool for Assessing Macromolecular Structure and Function in Living Cells [J] . Li Conggang, Zhao Jiajing, Cheng Kai, Annual Review of Analytical Chemistry . 2017,第期

机译：磁共振光谱作为评估大分子结构和活细胞功能的工具
2. Effects of exercise training on myocardial energy metabolism and ventricular function assessed by quantitative phosphorus-31 magnetic resonance spectroscopy and magnetic resonance imaging in dilated cardiomyopathy. [J] . Beer M, Wagner D, Myers J, Journal of the American College of Cardiology . 2008,第19期

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3. STUDY ON STRUCTURAL EVOLUTION CHARACTERISTICS OF STRUCTURAL COAL MACROMOLECULAR STRUCTURE BASED ON INFRARED SPECTROSCOPY AND NUCLEAR MAGNETIC RESONANCE [J] . Yongshuai Fu Fresenius environmental bulletin . 2020,第10期

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4. Functional Macromolecular Nano-materials based on Living Polymerization and Selfassembling ProcessFunctional Macromolecular Nano-materials based on Living Polymerization and Selfassembling ProcessFunctional Macromolecular Nano-materials based on Livi [C] . Tomokazu Iyoda, Kazuhito Watanabe, Yi Li Meeting,Division of Polymeric Material: Science and Engineering American Chemical Society . 2004

机译：基于活性聚合的功能性大分子纳米材料，基于生物聚合和自叠种过程官能官能官能官能官能分子纳米材料，基于Livi
5. Applications of solid state nuclear magnetic resonance spectroscopy as a tool for structure based drug design. [D] . Mukherjee, Sujoy. 2008

机译：固态核磁共振波谱作为基于结构药物设计的工具的应用。
6. Mitochondria-targeted antioxidant promotes recovery of skeletal muscle mitochondrial function after burn trauma assessed by in vivo31P nuclear magnetic resonance and electron paramagnetic resonance spectroscopy [O] . Valeria Righi, Caterina Constantinou, Dionyssios Mintzopoulos, -1

机译：通过体内评估针对线粒体的抗氧化剂可促进烧伤后骨骼肌线粒体功能的恢复31P核磁共振和电子顺磁共振光谱
7. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1. [O] . Upasana Tayal, Alexandros Kallifatidis, P. Garg, 2016

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8. Brain Function, Structure, and Neurochemistry After Tamoxifen/ Chemotherapy Assessed by Neuropsychologic Testing and H Magnetic Resonance Spectroscopy [R] . Chlebowski, R. 2002

机译：他莫昔芬/化疗后的脑功能，结构和神经化学评估由神经心理学测试和H磁共振光谱学评估

Magnetic Resonance Spectroscopy as a Tool for Assessing Macromolecular Structure and Function in Living Cells

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