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首页> 外文期刊>Annual review of cell and developmental biology >Cell Reprogramming: The Many Roads to Success
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Cell Reprogramming: The Many Roads to Success

机译：细胞重新编程：成功的许多道路

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摘要

Cellular reprogramming experiments from somatic cell types have demonstrated the plasticity of terminally differentiated cell states.Recent efforts in understanding the mechanisms of cellular reprogramming have begun to elucidate the differentiation trajectories along the reprogramming processes.In this review, we focus mainly on direct reprogramming strategies by transcription factors and highlight the variables that contribute to cell fate conversion outcomes.We review key studies that shed light on the cellular and molecular mechanisms by investigating differentiation trajectories and alternative cell states as well as transcription factor regulatory activities during cell fate reprogramming.Finally, we highlight a few concepts that we believe require attention, particularly when measuring the success of cell reprogramming experiments.
机译：来自躯体细胞类型的细胞重编程实验表明了终端差异化的细胞状态的可塑性。在理解细胞重编程机制方面已经开始阐明沿重编程过程阐明的差异轨迹。在本综述中，我们主要专注于直接重新编程策略 转录因子并突出有助于细胞命运转换结果的变量。我们审查了通过研究分化轨迹和替代细胞态以及在细胞命运重新编程过程中的转录因子调节活动来揭示细胞和分子机制的关键研究。最后，我们 突出一些我们认为需要注意的一些概念，特别是在测量细胞重编程实验的成功时。

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