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首页> 外文期刊>Annual review of cell and developmental biology >The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing
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The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing

机译：成人血缺陷的来源和动态：谱系追踪的见解

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The generation of all blood cell lineages (hematopoiesis) is sustained throughout the entire life span of adult mammals. Studies using cell transplantation identified the self-renewing, multipotent hematopoietic stem cells (HSCs) as the source of hematopoiesis in adoptive hosts and delineated a hierarchy of HSC-derived progenitors that ultimately yield mature blood cells. However, much less is known about adult hematopoiesis as it occurs in native hosts, i.e., without transplantation. Here we review recent advances in our understanding of native hematopoiesis, focusing in particular on the application of genetic lineage tracing in mice. The emerging evidence has established HSCs as the major source of native hematopoiesis, helped to define the kinetics of HSC differentiation, and begun exploring native hematopoiesis in stress conditions such as aging and inflammation. Major outstanding questions about native hematopoiesis still remain, such as its clonal composition, the nature of lineage commitment, and the dynamics of the process in humans.
机译：所有血细胞谱系（血液缺陷）的产生在成年哺乳动物的整个寿命期间都是持续的。使用细胞移植的研究鉴定了自我更新，多能造血干细胞（HSC）作为造产宿主中造血源的来源，并列出了HSC衍生的祖细胞的等级，最终得到成熟的血细胞。然而，大概少于成年血缺陷，因为它发生在天然宿主中，即没有移植。在这里，我们审查了我们对原生血液血清的理解的最新进展，特别是对小鼠遗传谱系追踪的应用。新兴的证据已将HSC建立为天然血缺陷的主要来源，有助于定义HSC分化的动力学，并开始探索衰老和炎症等压力条件下的天然血液血液。关于本地血液缺陷的主要出色问题仍然存在，例如其克隆组成，血统承诺的性质以及人类过程的动态。

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