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首页> 外文期刊>Annual review of cell and developmental biology >The Inherent Asymmetry of DNA Replication
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The Inherent Asymmetry of DNA Replication

机译：DNA复制的固有不对称性

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Semiconservative DNA replication has provided an elegant solution to the fundamental problem of how life is able to proliferate in a way that allows cells, organisms, and populations to survive and replicate many times over. Somewhat lost, however, in our admiration for this mechanism is an appreciation for the asymmetries that occur in the process of DNA replication. As we discuss in this review, these asymmetries arise as a consequence of the structure of the DNA molecule and the enzymatic mechanism of DNA synthesis. Increasing evidence suggests that asymmetries in DNA replication are able to play a central role in the processes of adaptation and evolution by shaping the mutagenic landscape of cells. Additionally, in eukaryotes, recent work has demonstrated that the inherent asymmetries in DNA replication may play an important role in the process of chromatin replication. As chromatin plays an essential role in defining cell identity, asymmetries generated during the process of DNA replication may play critical roles in cell fate decisions related to patterning and development.
机译：半透明DNA复制为寿命如何能够以一种允许细胞，生物和种群生存并重复多次来繁殖并复制的基本问题提供了优雅的解决方案。然而，在我们对这种机制的钦佩中有点丢失是对DNA复制过程中发生的不对称的欣赏。正如我们在本综述中讨论的那样，由于DNA分子的结构和DNA合成的酶促机制，这些不对称的非对称性出现。越来越多的证据表明DNA复制中的不对称性能够通过塑造细胞的致突变景观来在适应和演化过程中发挥核心作用。此外，在真核生物中，最近的工作表明，DNA复制中固有的不对称可能在染色质复制过程中起重要作用。由于染色质在定义细胞身份中起重要作用，在DNA复制过程中产生的不对称可能在与图案和开发相关的细胞命运决策中起重要作用。

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